Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513 (Q24676214)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16184188%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513 (English)

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7 January 2020

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5

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7 January 2020

author name string

Luanda J Pym

1

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7 January 2020

Susan M Cook

2

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7 January 2020

Thomas Rosahl

3

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7 January 2020

Ruth M McKernan

4

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7 January 2020

language of work or name

English

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publication date

1 November 2005

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British Journal of Pharmacology

7 January 2020

published in

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7 January 2020

volume

146

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7 January 2020

issue

6

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7 January 2020

page(s)

817-825

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Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors

7 January 2020

cites work

1 reference

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Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]

7 April 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 April 2017

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Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2

7 April 2017

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Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

7 April 2017

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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

7 April 2017

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Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

7 April 2017

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Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

28 September 2017

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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

28 September 2017

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A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits

28 September 2017

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Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

28 September 2017

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Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.

28 September 2017

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Which GABAA-receptor subtypes really occur in the brain?

28 September 2017

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[123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain

28 September 2017

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GABAA/benzodiazepine receptor heterogeneity: neurophysiological implications.

28 September 2017

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Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

28 September 2017

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Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit

28 September 2017

1 reference

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The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

28 September 2017

1 reference

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GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

28 September 2017

1 reference

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Imaging of the super high affinity binding sites for [3H]Ro15-4513 in rat hippocampus: comparison between in vitro and in vivo binding.

30 May 2018

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A subclass of GABAA/benzodiazepine receptor exclusively localized in the limbic system.

30 May 2018

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Comparison of several benzodiazepine receptor ligands in two models of anxiolytic activity in the mouse: an analysis based on fractional receptor occupancies.

30 May 2018

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Diazepam-insensitive [3H]Ro 15-4513 binding in intact cultured cerebellar granule cells.

30 May 2018

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In vivo labeling of central benzodiazepine receptors with the partial inverse agonist [3H]Ro 15-4513.

30 May 2018

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In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.

30 May 2018

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The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam

30 May 2018

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In vivo binding of [11C]Ro15-4513 in human brain measured with PET

30 May 2018

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Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous system

30 May 2018

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11CRo 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography

30 May 2018

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Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies

30 May 2018

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High affinity ligands for ‘diazepam-insensitive’ benzodiazepine receptors

30 May 2018

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In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.

30 May 2018

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Analysis of the set of GABA(A) receptor genes in the human genome.

28 November 2018

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Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751217

Molecular and neuronal substrate for the selective attenuation of anxiety.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751217

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751217

Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751217

Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751217

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16184188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16184188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of [methyl-3H]L655,708 and [ethyl-3H]RY80 as putative PET ligands for central GABA(A) receptors containing alpha5 subunit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16184188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJP.0706392

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16184188%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16184188%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference