Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization (Q24674862)

2

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Mortimer Poncz

3

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Steven F Dowdy

4

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Gerd A Blobel

5

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John D Crispino

X-linked thrombocytopenia caused by a novel mutation of GATA-1

6

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language of work or name

English

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publication date

15 June 2007

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published in

Blood

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volume

109

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page(s)

5199-207

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issue

12

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cites work

1 reference

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

7 April 2017

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Growth suppression by p16ink4 requires functional retinoblastoma protein

7 April 2017

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CDK inhibitors: positive and negative regulators of G1-phase progression

7 April 2017

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The retinoblastoma protein and cell cycle control

7 April 2017

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Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins

7 April 2017

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GATA1 in normal and malignant hematopoiesis

7 April 2017

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Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

7 April 2017

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Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo

7 April 2017

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

7 April 2017

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The regulation of E2F by pRB-family proteins

7 April 2017

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The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

7 April 2017

1 reference

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A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

7 April 2017

1 reference

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Inhibitors of mammalian G1 cyclin-dependent kinases

7 April 2017

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Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

7 April 2017

1 reference

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The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth

28 September 2017

1 reference

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

28 September 2017

1 reference

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AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression

28 September 2017

1 reference

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Context-dependent regulation of GATA-1 by friend of GATA-1.

28 September 2017

1 reference

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Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

28 September 2017

1 reference

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RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

28 September 2017

1 reference

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Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors

28 September 2017

1 reference

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Roads to polyploidy: the megakaryocyte example

28 September 2017

1 reference

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Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

28 September 2017

1 reference

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Role of p21(Cip1/Waf1) in cell-cycle exit of endomitotic megakaryocytes

28 September 2017

1 reference

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The Drosophila cyclin D-Cdk4 complex promotes cellular growth

28 September 2017

1 reference

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Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression

28 September 2017

1 reference

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Molecular cloning and sequence analysis of the promoter region of mouse cyclin D1 gene: implication in phorbol ester-induced tumour promotion

28 September 2017

1 reference

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Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.

28 September 2017

1 reference

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1.

28 September 2017

1 reference

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Consequences of GATA-1 deficiency in megakaryocytes and platelets

28 September 2017

1 reference

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p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells

28 September 2017

1 reference

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A role for cyclin D3 in the endomitotic cell cycle

28 September 2017

1 reference

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Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line

28 September 2017

1 reference

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Thrombopoietin signal transduction in purified murine megakaryocytes

28 September 2017

1 reference

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Centrifugal enhancement of retroviral mediated gene transfer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Mouse development and cell proliferation in the absence of D-cyclins.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Selective modulation of the cyclin B/CDK1 and cyclin D/CDK4 complexes during in vitro human megakaryocyte development

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890844

Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis

28 November 2018

1 reference

12 December 2020

Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation

1 reference

12 December 2020

Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes

1 reference

12 December 2020

The relationship between human megakaryocyte nuclear DNA content and gene expression

1 reference

12 December 2020

Cyclin D3 is essential for megakaryocytopoiesis

1 reference

12 December 2020

Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand

1 reference

12 December 2020

Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex

1 reference

12 December 2020

10.1182/BLOOD-2006-11-059378

Identifiers

DOI

1 reference

1357686

1357686

1 reference

1 reference

1 reference