Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1 (Q24672749)

1

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Rodolphe Carpentier

2

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Pascaline Ségard

3

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Cécile Olivé-Cren

4

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Philippe Lefebvre

ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif

5

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language of work or name

English

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publication date

2006

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published in

Nucleic Acids Research

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volume

34

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issue

19

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page(s)

5515-27

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cites work

1 reference

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Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers

7 April 2017

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A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

7 April 2017

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Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex

7 April 2017

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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

7 April 2017

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Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate

7 April 2017

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The coregulator exchange in transcriptional functions of nuclear receptors

7 April 2017

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p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus

7 April 2017

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Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

7 April 2017

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Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors

7 April 2017

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RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

7 April 2017

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Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

7 April 2017

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A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1

7 April 2017

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p57(Kip2) cooperates with Nurr1 in developing dopamine cells

7 April 2017

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Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

7 April 2017

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Dopamine neuron agenesis in Nurr1-deficient mice

7 April 2017

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Identification of a new brain-specific transcription factor, NURR1

7 April 2017

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The molecular basis of vitamin D receptor and beta-catenin crossregulation.

7 April 2017

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Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival

28 September 2017

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Role of extracellular signal regulated kinase 5 in neuronal survival.

28 September 2017

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The neurobiology of dopamine signaling

28 September 2017

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Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

28 September 2017

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Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1.

28 September 2017

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PIASγ Represses the Transcriptional Activation Induced by the Nuclear Receptor Nurr1

28 September 2017

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Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

28 September 2017

https://api.crossref.org/works/10.1093%2FNAR%2FGKL712

Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment

21 January 2018

1 reference

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Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins

28 September 2017

1 reference

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Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro

28 September 2017

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Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

28 September 2017

1 reference

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Signaling pathways for PC12 cell differentiation: making the right connections

28 September 2017

1 reference

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Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.

28 September 2017

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Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

28 September 2017

1 reference

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Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

bcl-2 inhibits death of central neural cells induced by multiple agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKL712

The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKL712

Activity of the Nurr1 Carboxyl-terminal Domain Depends on Cell Type and Integrity of the Activation Function 2

21 January 2018

2 references

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKL712

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/17020917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636490

Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17020917

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The NGFI-B subfamily of the nuclear receptor superfamily (review)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17020917