Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors (Q24656247)

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

volume

106

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issue

1

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page(s)

29-36

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cites work

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

7 April 2017

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

7 April 2017

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

7 April 2017

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Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology

7 April 2017

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The binding of transformed aromatic hydrocarbon (Ah) receptor to its DNA recognition site is not affected by metal depletion

7 April 2017

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Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver

7 April 2017

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Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis

7 April 2017

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The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

7 April 2017

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Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

28 September 2017

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

28 September 2017

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Presence and inducibility of peroxisomes in a human glioblastoma cell line.

28 September 2017

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Induction of cytochrome P4501A1.

28 September 2017

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

28 September 2017

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Effects of perfluoro-n-decanoic acid on the respiratory activity of isolated rat liver mitochondria

28 September 2017

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Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid

28 September 2017

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Effects of peroxisome proliferators on rat liver phospholipids: sphingomyelin degradation may be involved in hepatotoxic mechanism of perfluorodecanoic acid.

30 May 2018

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Induction of the CYP4A subfamily by perfluorodecanoic acid: the rat and the guinea pig as susceptible and non-susceptible species

30 May 2018

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Hepatic oxidative stress and related defenses during treatment of mice with acetylsalicylic acid and other peroxisome proliferators

30 May 2018

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Pathological and hepatic ultrastructural effects of a single dose of perfluoro-n-decanoic acid in the rat, hamster, mouse, and guinea pig.

30 May 2018

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Disposition of perfluorodecanoic acid in male and female rats

30 May 2018

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Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines

30 May 2018

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Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002.

21 January 2018

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Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile

21 January 2018

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Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).

21 January 2018

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Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

21 January 2018

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Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways

21 January 2018

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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Occurrence of perfluoroalkyl surfactants in water, fish, and birds from New York State

21 January 2018

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Perflouroalkyl contaminants in liver tissue from East Greenland polar bears (Ursus maritimus).

21 January 2018

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Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.

21 January 2018

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Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

28 November 2018

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Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China

28 November 2018

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12 December 2020

Induction by perfluorinated fatty acids with different carbon chain length of peroxisomal beta-oxidation in the liver of rats

1 reference

12 December 2020

The biochemical toxicity of perfluorodecanoic acid in the mouse is different from that of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

12 December 2020

Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats

1 reference

12 December 2020

Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats

1 reference

12 December 2020

Is Fish a Major Source of Fluorinated Surfactants and Repellents in Humans Living on the Baltic Coast?

1 reference

12 December 2020

Isomer distribution of perfluorocarboxylates in human blood: potential correlation to source.

1 reference

12 December 2020

Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine

1 reference

12 December 2020