TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing (Q24651520)

1

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I-Fan Wang

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Li Hung

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Woan-Yuh Tarn

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C-K James Shen

Journal of Biological Chemistry

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language of work or name

English

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publication date

24 October 2008

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published in

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volume

283

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page(s)

28852-9

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issue

43

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cites work

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hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1

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TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

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Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1

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SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1

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Enhancer-dependent splicing of FGFR1 alpha-exon is repressed by RNA interference-mediated down-regulation of SRp55.

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Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

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Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

28 September 2017

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A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

28 September 2017

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The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites.

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Synthesis and purification of large amounts of RNA oligonucleotides.

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TDP-43: an emerging new player in neurodegenerative diseases

30 May 2018

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TDP-43 in differential diagnosis of motor neuron disorders

28 November 2018

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TDP43 depletion rescues aberrant CFTR exon 9 skipping.

28 November 2018

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hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing

28 November 2018

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12 December 2020

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

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12 December 2020

An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy

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12 December 2020

SMN oligomerization defect correlates with spinal muscular atrophy severity

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12 December 2020

An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN

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12 December 2020