Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities (Q24651500)

Ed Laufer

8

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David M. Virshup

David M Virshup

5

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A B Firulli

9

Anthony B Firulli

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Beth A Firulli

1

Beth A Firulli

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author name string

Dayana Krawchuk

2

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Victoria E Centonze

3

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Simon J Conway

6

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Peter Cserjesi

The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function

7

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language of work or name

English

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publication date

April 2005

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published in

Nature Genetics

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volume

37

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page(s)

373-81

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issue

4

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cites work

1 reference

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Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location

7 April 2017

1 reference

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Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

7 April 2017

1 reference

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The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist

7 April 2017

1 reference

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Mutations of the TWIST gene in the Saethre-Chotzen syndrome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

7 April 2017

1 reference

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A twist code determines the onset of osteoblast differentiation

7 April 2017

1 reference

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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

7 April 2017

1 reference

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Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis

7 April 2017

1 reference

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Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding

7 April 2017

1 reference

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Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

7 April 2017

1 reference

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twist is required in head mesenchyme for cranial neural tube morphogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

A series of normal stages in the development of the chick embryo

7 April 2017

2 references

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7 April 2017

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors

7 April 2017

1 reference

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Twist functions in mouse development.

28 September 2017

1 reference

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A Twist in fate: evolutionary comparison of Twist structure and function

28 September 2017

1 reference

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Comparative biological responses to human Sonic, Indian, and Desert hedgehog

28 September 2017

1 reference

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The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Mutations in the human TWIST gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

A comprehensive screen for TWIST mutations in patients with craniosynostosis identifies a new microdeletion syndrome of chromosome band 7p21.1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

A subclass of bHLH proteins required for cardiac morphogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Regulation of muscle transcription by the MyoD family. The heart of the matter

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

PKA, PKC, and the Protein Phosphatase 2A Influence HAND Factor Function

28 September 2017

1 reference

Crossref

Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.

21 January 2018

1 reference

Crossref

Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Developmental expression of chick twist and its regulation during limb patterning.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Mutations in the basic domain and the loop-helix II junction of TWIST abolish DNA binding in Saethre-Chotzen syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2568820

The number of polarizing region cells required to specify additional digits in the developing chick wing

28 November 2018

1 reference

Crossref

Fluorescence resonance energy transfer imaging microscopy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15735646

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted gene misexpression in chick limb buds using avian replication-competent retroviruses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15735646

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15735646

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG1525

1 reference

Dimensions Publication ID

1833026

1036020810

0 references

1833026

1 reference

1 reference

1 reference