AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL (Q24651465)

2

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J Mestan

3

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S Cowan-Jacob

4

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A Ray

5

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J D Griffin

British Journal of Cancer

6

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language of work or name

English

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publication date

19 June 2006

4 references

3 April 2019

17 September 2019

14 September 2020

17 December 2020

4 references

3 April 2019

17 September 2019

14 September 2020

17 December 2020

94

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issue

12

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page(s)

1765-9

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cites work

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

7 April 2017

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

7 April 2017

1 reference

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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

7 April 2017

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 April 2017

1 reference

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Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study

7 April 2017

1 reference

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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo

28 September 2017

1 reference

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AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia

28 September 2017

1 reference

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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

28 September 2017

1 reference

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

28 September 2017

1 reference

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Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases

28 September 2017

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A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias

28 September 2017

1 reference

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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

28 September 2017

1 reference

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PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

28 September 2017

1 reference

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

30 May 2018

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Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds.

30 May 2018

1 reference

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Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia

21 January 2018

1 reference

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Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

21 January 2018

1 reference

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Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

21 January 2018

1 reference

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The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603170

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

21 January 2018

1 reference

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A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603170

OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603170

Definition of the accelerated phase of chronic myelogenous leukemia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16721371

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16721371

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6603170

1 reference

Dimensions Publication ID

2786079

1030812086

0 references

2786079

1 reference

1 reference

1 reference