Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells (Q24648838)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10557354%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells (English)

1 reference

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1 November 2019

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all-trans-4-hydroxyretinol

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ChEBI release 2020-05-28

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ChEBI release 2020-05-28

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3

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1 November 2019

author name string

M A Lane

1

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1 November 2019

A C Chen

2

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1 November 2019

F Derguini

4

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1 November 2019

L J Gudas

5

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1 November 2019

language of work or name

English

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publication date

1 November 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10557354%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

1 November 2019

published in

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1 November 2019

volume

96

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1 November 2019

page(s)

13524-13529

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1 November 2019

issue

23

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Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1 November 2019

cites work

1 reference

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cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450

7 April 2017

1 reference

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

7 April 2017

1 reference

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DNA sequencing with chain-terminating inhibitors

7 April 2017

1 reference

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CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

7 April 2017

1 reference

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Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

7 April 2017

1 reference

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Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

7 April 2017

1 reference

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Essential role of STAT3 for embryonic stem cell pluripotency

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

4-Oxoretinol, a metabolite of retinol in the human promyelocytic leukemia cell line NB4, induces cell growth arrest and granulocytic differentiation.

28 September 2017

1 reference

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Human breast cancer cells and normal mammary epithelial cells: retinol metabolism and growth inhibition by the retinol metabolite 4-oxoretinol.

28 September 2017

1 reference

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Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells

28 September 2017

1 reference

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Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.

28 September 2017

1 reference

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Novel retinoic acid receptor ligands in Xenopus embryos

28 September 2017

1 reference

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Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

28 September 2017

1 reference

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Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases.

28 September 2017

1 reference

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The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

28 September 2017

1 reference

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Transport and storage of vitamin A.

28 September 2017

1 reference

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Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

An analysis of retinoic acid-induced gene expression and metabolism in AB1 embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23981

Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.

28 September 2017

1 reference

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Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

30 May 2018

1 reference

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Intracellular Signaling by 14-hydroxy-4,14- Retro -Retinol

30 May 2018

1 reference

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Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations

30 May 2018

1 reference

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A molecular basis for retinoic acid-induced axial truncation.

30 May 2018

1 reference

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Metabolism of all-trans-retinol in normal human cell strains and squamous cell carcinoma (SCC) lines from the oral cavity and skin: reduced esterification of retinol in SCC lines.

21 January 2018

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Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

28 November 2018

1 reference

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Essential function of LIF receptor in motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.23.13524

Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis

21 January 2018

1 reference

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Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials

21 January 2018

1 reference

12 December 2020

Metabolism of all-trans-retinol and all-trans-retinoic acid in rabbit tracheal epithelial cells in culture

1 reference

12 December 2020

Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells

1 reference

12 December 2020

Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes

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12 December 2020

Identifiers

DOI

10.1073/PNAS.96.23.13524

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10557354%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10557354%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference