Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+ (Q24647839)

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author name string

A Dinudom

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P Komwatana

3

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J A Young

4

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D I Cook

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

9 June 1998

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published in

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volume

95

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page(s)

7169-73

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issue

12

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cites work

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Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome

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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

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A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity

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Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

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Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

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Cytosolic Na+ controls and epithelial Na+ channel via the Go guanine nucleotide-binding regulatory protein

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Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of Na pump

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The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.95.12.7169

Control of the amiloride-sensitive Na+ current in salivary duct cells by extracellular sodium.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.95.12.7169

The GTP-binding protein, Go, regulates neuronal calcium channels

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.95.12.7169

Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry

21 January 2018

1 reference

12 December 2020

Amiloride-sensitive Na+ current in the granular duct cells of mouse mandibular glands

1 reference

12 December 2020

Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubule

1 reference

12 December 2020

Na+ and Cl- conductances are controlled by cytosolic Cl- concentration in the intralobular duct cells of mouse mandibular glands

1 reference

12 December 2020

Characterization of the Cl- conductance in the granular duct cells of mouse mandibular glands

1 reference

12 December 2020

A forskolin-activated Cl- current in mouse mandibular duct cells

1 reference

12 December 2020

Control of the amiloride-sensitive Na+ current in mouse salivary ducts by intracellular anions is mediated by a G protein

1 reference

12 December 2020

Peptide block of constitutively activated Na+ channels in Liddle's disease

1 reference

12 December 2020

Activators of epithelial Na+ channels inhibit cytosolic feedback control. Evidence for the existence of a G protein-coupled receptor for cytosolic Na+

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.12.7169

1 reference

4543551

ADS bibcode

1998PNAS...95.7169D

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4543551

1 reference

1 reference

1 reference