Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (Q24647376)

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Joseph R Bishop

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Erin M Foley

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Jon C Gonzales

4

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Ingrid R Niesman

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Jeffrey D Esko

Journal of Clinical Investigation

7

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language of work or name

English

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publication date

November 2009

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published in

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volume

119

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page(s)

3236-45

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issue

11

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cites work

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Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation

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Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism

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Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

27 September 2017

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Acylation of CD44 and its association with lipid rafts are required for receptor and hyaluronan endocytosis

27 September 2017

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Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway

27 September 2017

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Syndecan-1 expression in epithelial cells is induced by transforming growth factor beta through a PKA-dependent pathway

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Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway

27 September 2017

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Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells

27 September 2017

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Heparan sulfate proteoglycan as a plasma membrane carrier

27 September 2017

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The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolism

27 September 2017

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27 September 2017

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Lipoprotein lipase- and hepatic triglyceride lipase- promoted very low density lipoprotein degradation proceeds via an apolipoprotein E-dependent mechanism

27 September 2017

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Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters

27 September 2017

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Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

27 September 2017

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Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase

27 September 2017

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Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

27 September 2017

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Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes

27 September 2017

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The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro

27 September 2017

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Uptake of hypertriglyceridemic very low density lipoproteins and their remnants by HepG2 cells: the role of lipoprotein lipase, hepatic triglyceride lipase, and cell surface proteoglycans

27 September 2017

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Oligosaccharide sequences of endothelial cell surface heparan sulfate proteoglycan with affinity for lipoprotein lipase

27 September 2017

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Recycling receptors: The round-trip itinerary of migrant membrane proteins

27 September 2017

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Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway

27 September 2017

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New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.

30 May 2018

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Transmembrane and cytoplasmic domains of syndecan mediate a multi-step endocytic pathway involving detergent-insoluble membrane rafts

30 May 2018

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Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism

30 May 2018

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Cell-surface heparan sulfate proteoglycans: dynamic molecules mediating ligand catabolism.

30 May 2018

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Immunocytochemistry of cell surface heparan sulfate proteoglycan in mouse tissues. A light and electron microscopic study

30 May 2018

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Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing

30 May 2018

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28 November 2018

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Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3.

28 November 2018

1 reference

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Sustained somatic gene inactivation by viral transfer of Cre recombinase.

28 November 2018

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Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769193

Two new monoclonal antibody-based enzyme-linked assays of apolipoprotein B

28 November 2018

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Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans

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12 December 2020

Liver heparan sulfate structure. A novel molecular design

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12 December 2020

Heparan sulfate proteoglycan expression in normal human liver

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12 December 2020

Gene expression of syndecans and betaglycan in isolated rat liver cells

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12 December 2020

Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP)

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12 December 2020

Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both

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Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

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The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis

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Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1

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12 December 2020

Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence

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12 December 2020

Apolipoprotein E5 (Glu212-->Lys): increased binding to cell surface proteoglycans but decreased uptake and lysosomal degradation in cultured fibroblasts

1 reference

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Heparan sulfate proteoglycan-mediated uptake of apolipoprotein E-triglyceride-rich lipoprotein particles: a major pathway at physiological particle concentrations

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The elusive role of heparan sulfate in Toxoplasma gondii infection

1 reference

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Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice

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Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women

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Interactions of lipoproteins with proteoglycans

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Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen)

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Identifiers

DOI

10.1172/JCI38251

1 reference

826598

826598

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1 reference

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