WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter (Q24646108)

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12 January 2020

title

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter (English)

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12 January 2020

2

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12 January 2020

Gerardo Gamba

5

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12 January 2020

author name string

Pedro San-Cristobal

1

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12 January 2020

Norma Vázquez

3

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12 January 2020

Norma A Bobadilla

4

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12 January 2020

language of work or name

English

0 references

publication date

13 August 2008

1 reference

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American Journal of Physiology - Renal Physiology

12 January 2020

published in

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12 January 2020

volume

295

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12 January 2020

page(s)

F1199-206

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issue

4

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Domains of WNK1 kinase in the regulation of ROMK1

12 January 2020

cites work

1 reference

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The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

7 April 2017

1 reference

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WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

7 April 2017

1 reference

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Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

7 April 2017

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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

7 April 2017

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Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter

7 April 2017

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Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

7 April 2017

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The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

7 April 2017

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Molecular physiology of cation-coupled Cl? cotransport: the SLC12 family

7 April 2017

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Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

7 April 2017

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Human hypertension caused by mutations in WNK kinases

7 April 2017

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Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding

7 April 2017

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Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

7 April 2017

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The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

7 April 2017

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

7 April 2017

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WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

7 April 2017

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Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney

7 April 2017

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Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

7 April 2017

1 reference

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WNK kinases and renal sodium transport in health and disease: an integrated view

27 September 2017

1 reference

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WNK4-mediated regulation of renal ion transport proteins

27 September 2017

1 reference

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Cotransporters, WNKs and hypertension: important leads from the study of monogenetic disorders of blood pressure regulation

27 September 2017

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WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters

27 September 2017

1 reference

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WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells

27 September 2017

1 reference

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WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

27 September 2017

1 reference

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WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

27 September 2017

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WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

27 September 2017

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Properties of WNK1 and implications for other family members

27 September 2017

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Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

27 September 2017

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27 September 2017

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Regulation of K-Cl cotransport: from function to genes

27 September 2017

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Regulation of Na-K-2Cl cotransport by phosphorylation and protein-protein interactions

27 September 2017

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K-Cl cotransport: properties and molecular mechanism

27 September 2017

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Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

27 September 2017

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Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.

30 May 2018

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WNK4 kinase is a negative regulator of K+-Cl- cotransporters.

30 May 2018

1 reference

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Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.90396.2008

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

21 January 2018

1 reference

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WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

21 January 2018

1 reference

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Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18701621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18701621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPRENAL.90396.2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18701621%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18701621%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference