NS5 of dengue virus mediates STAT2 binding and degradation (Q24644381)

viral nonstructural proteins

inferred from abstract

1 reference

PubMed ID

19279106

Signal transducer and activator of transcription 2

1 reference

PubMed ID

19279106

modulation by virus of host process

0 references

author

Adolfo García-Sastre

4

0 references

Pei-Yong Shi

3

object named as

Pei-Yong Shi

0 references

Maudry Laurent-Rolle

2

object named as

Maudry Laurent-Rolle

0 references

Joseph Ashour

on focus list of Wikimedia project

1

object named as

Joseph Ashour

0 references

language of work or name

English

0 references

publication date

June 2009

0 references

published in

Journal of Virology

0 references

volume

83

0 references

page(s)

5408-18

0 references

issue

11

0 references

ScienceSource

0 references

cites work

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7 April 2017

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The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals

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Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

7 April 2017

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Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase

7 April 2017

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cDNA structures and regulation of two interferon-induced human Mx proteins

7 April 2017

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Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism

7 April 2017

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Triaryl pyrazoline compound inhibits flavivirus RNA replication

7 April 2017

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Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist

7 April 2017

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Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

7 April 2017

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7 April 2017

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Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicase

7 April 2017

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7 April 2017

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UBP43 (USP18) specifically removes ISG15 from conjugated proteins

7 April 2017

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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

7 April 2017

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A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

7 April 2017

1 reference

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A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state

7 April 2017

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Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

7 April 2017

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Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3

7 April 2017

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Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins

7 April 2017

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Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins

7 April 2017

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Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses

7 April 2017

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Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain

27 September 2017

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Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists

27 September 2017

1 reference

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Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice

27 September 2017

1 reference

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West Nile virus inhibits the signal transduction pathway of alpha interferon

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling

27 September 2017

1 reference

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Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins

27 September 2017

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Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation

27 September 2017

1 reference

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All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a thresh

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Transmembrane signaling by the alpha subunit of the type I interferon receptor is essential for activation of the JAK kinases and the transcriptional factor ISGF3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Molecular mechanisms of interferon action: interferon-mediated phosphorylation of ribosome-associated protein P1 and protein synthesis initiation factor eIF-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Methylation status of intracellular dengue type 2 40 S RNA

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

The C protein of measles virus inhibits the type I interferon response

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2681973

Immune response in Stat2 knockout mice

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19279106

12 December 2020

inferred from PubMed ID database lookup

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19279106

12 December 2020

inferred from PubMed ID database lookup

Knockout and reconstitution of a functional human type I interferon receptor complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19279106

12 December 2020