Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone (Q24643917)

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English	Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone	scientific article

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3 November 2019

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone (English)

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3 November 2019

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David W. Russell

7

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3 November 2019

Ingemar Björkhem

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3 November 2019

Ingemar Björkhem

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K A Rose

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G Stapleton

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K Dott

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3 November 2019

M P Kieny

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R Best

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M Schwarz

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3 November 2019

J Seckl

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publication date

1 May 1997

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3 November 2019

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6

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Proceedings of the National Academy of Sciences of the United States of America

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94

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3 November 2019

4925-4930

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10

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3 November 2019

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases

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7 April 2017

Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone

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7 April 2017

Progesterone receptor-mediated effects of neuroactive steroids

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Neuroactive steroid actions at the GABAA receptor

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7 April 2017

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase

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7 April 2017

Cholesterol 7 alpha-Hydroxylase. 2. Biochemical Properties and Participation of Endogenous Cholesterol in the Assay in vitro

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7 April 2017

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

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7 April 2017

Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene

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7 April 2017

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis

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7 April 2017

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

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27 September 2017

A novel cytochrome P450 expressed primarily in brain

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27 September 2017

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density.

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27 September 2017

7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase

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27 September 2017

Pre- and postnatal ontogeny of aromatase cytochrome P450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridization

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27 September 2017

cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily

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27 September 2017

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus

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27 September 2017

A novel P450 expressed at the high level in rat brain

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27 September 2017

Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.

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27 September 2017

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27 September 2017

3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.

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27 September 2017

Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive

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27 September 2017

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

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27 September 2017

Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression

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27 September 2017

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

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27 September 2017

Androgen metabolism in the brain

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27 September 2017

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor

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27 September 2017

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

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27 September 2017

Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons.

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27 September 2017

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27 September 2017

Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice.

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30 May 2018

A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1 beta. Characterization in the immature rat ovary

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30 May 2018

Expression of cytochrome P450 side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase in the rat central nervous system: a study by polymerase chain reaction and in situ hybridization.

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30 May 2018

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

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30 May 2018

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30 May 2018

Steroid 7 alpha-hydroxylase of rat testes

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30 May 2018

Subcellular distribution of cytochrome P-450 in the brain.

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30 May 2018

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30 May 2018

Immunohistochemical localization of cytochrome P-450 in rat brain

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30 May 2018

Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450b,e, and P-450c,d.

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30 May 2018

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30 May 2018

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex

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30 May 2018

Dehydroepiandrosterone sulfate improves memory in aging mice.

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30 May 2018

Neuro-steroids: 3 beta-hydroxy-delta 5-derivatives in rat and monkey brain.

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30 May 2018

Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain.

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30 May 2018

Modulation of the GABAA receptor by progesterone metabolites.

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30 May 2018

Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1)

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30 May 2018

Modulation of the GABAA receptor complex by steroids in slices of rat cuneate nucleus

1 reference

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30 May 2018

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor.

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30 May 2018

44 P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography

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30 May 2018

Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1 reference

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30 May 2018

Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice

1 reference

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30 May 2018

Microsomal cytochrome P450 in human brain regions

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30 May 2018

5β-Pregnan-3β-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex

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30 May 2018

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30 May 2018

7 alpha-Hydroxylation of the adrenal androgens dehydroepiandrosterone and androst-5-ene-3 beta, 17 beta-diol predominates in differentiating human adipose stromal cells.

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28 November 2018

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.

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28 November 2018

The effects of pregnenolone sulfate and ethylestrenol on retention of a passive avoidance task.

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28 November 2018

Purification of multiple forms of cytochrome P450 from a human brain and reconstitution of catalytic activities.

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28 November 2018

Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.

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28 November 2018

The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task.

1 reference

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28 November 2018

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.

1 reference

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28 November 2018

Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors.

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28 November 2018

Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels.

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28 November 2018

Steroid synthesis in rat brain cell cultures

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28 November 2018

A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brain

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12 December 2020

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Cholesterol is converted to 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7 alpha-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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Metabolism of dehydroepiandrosterone by cultured human adipose stromal cells: identification of 7 alpha-hydroxydehydroepiandrosterone as a major metabolite using high performance liquid chromatography and mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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Neurosteroidogenesis in rat retinas

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450s of the 4A subfamily in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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Distribution and regulation of 5 alpha-androstane-3 beta,17 beta-diol hydroxylase in the rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9144166

12 December 2020

based on heuristic

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Induction of glutamate synthase during nodule development in lupin

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7 January 2021

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10.1073/PNAS.94.10.4925

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3 November 2019

1997PNAS...94.4925R

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3 November 2019

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3 November 2019

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