Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression (Q24633879)

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7 February 2020

title

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression (English)

1 reference

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7 February 2020

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7

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7 February 2020

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Evette S Radisky

1 reference

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7 February 2020

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Daniel W Visscher

1 reference

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7 February 2020

Melody L. Stallings-Mann

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object named as

Melody L Stallings-Mann

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7 February 2020

author name string

Jens Waldmann

2

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7 February 2020

Ying Zhang

3

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7 February 2020

Erin Miller

4

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7 February 2020

Mona L Gauthier

5

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7 February 2020

Alan P Fields

9

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7 February 2020

Derek C Radisky

10

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7 February 2020

language of work or name

English

0 references

publication date

1 July 2012

1 reference

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Science Translational Medicine

7 February 2020

published in

1 reference

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7 February 2020

volume

4

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7 February 2020

page(s)

142ra95

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issue

142

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Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

7 February 2020

cites work

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7 April 2017

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7 April 2017

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Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

7 April 2017

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

7 April 2017

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7 April 2017

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Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.

7 April 2017

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Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis

27 September 2017

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The essence of senescence

27 September 2017

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The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

27 September 2017

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Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells.

27 September 2017

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Caveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cell

27 September 2017

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Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

27 September 2017

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Age-associated changes of extracellular matrix collagen impair lung cancer cell migration

27 September 2017

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Decreased expression of intelectin 1 in the human airway epithelium of smokers compared to nonsmokers

27 September 2017

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Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells

27 September 2017

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B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival

27 September 2017

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Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

27 September 2017

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Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung

27 September 2017

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Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival

27 September 2017

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TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease

27 September 2017

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Matrix metalloproteinase-induced malignancy in mammary epithelial cells

27 September 2017

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Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

27 September 2017

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Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition

27 September 2017

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Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium

27 September 2017

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Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

27 September 2017

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27 September 2017

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Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium

27 September 2017

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The role of Rho GTPases in disease development

27 September 2017

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

27 September 2017

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Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion

27 September 2017

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Ras and Rho GTPases: a family reunion

27 September 2017

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Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

27 September 2017

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Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

27 September 2017

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Modeling human lung cancer in mice: similarities and shortcomings

27 September 2017

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Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

27 September 2017

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Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties

27 September 2017

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Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression

27 September 2017

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Tumour biology: senescence in premalignant tumours

27 September 2017

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Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.

30 May 2018

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30 May 2018

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Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells.

30 May 2018

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The significance of matrix metalloproteinases during early stages of tumor progression

21 January 2018

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Demonstration in vivo that stromelysin-3 functions through its proteolytic activity.

21 January 2018

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Conditional gene expression in the respiratory epithelium of the mouse.

21 January 2018

1 reference

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The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis.

21 January 2018

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Tnfa and Il‐10 deficiencies have contrasting effects on lung tumor susceptibility: Gender‐dependent modulation of IL‐10 haploinsufficiency

21 January 2018

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At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.

21 January 2018

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Maintenance of the mouse type II cell phenotype in vitro

21 January 2018

1 reference

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Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22786680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Epithelial-mesenchymal transition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22786680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Twisted epithelial-mesenchymal transition blocks senescence

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22786680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.3004062

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22786680%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22786680%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

2 references