Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228) (Q24633204)

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English	Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)	scientific article

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scholarly article

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title

Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228) (English)

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1 reference

ChEBI release 2020-05-28

Thomas J Greshock

1

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Deidre M Johns

series ordinal

2

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Yasuo Noguchi

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3

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Robert M Williams

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4

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language of work or name

English

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publication date

21 February 2008

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published in

Organic Letters

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volume

10

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issue

4

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page(s)

613-6

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cites work

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

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PubMed Central

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Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma

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Histone deacetylase inhibitors--a new tool to treat cancer

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27 September 2017

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice

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27 September 2017

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination

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PubMed Central

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27 September 2017

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

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27 September 2017

Total Synthesis of the Depsipeptide FR-901375

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28 November 2018

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases

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Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors

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Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates

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28 November 2018

Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor

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Asymmetric Samarium-Reformatsky Reaction of Chiral alpha-Bromoacetyl-2-oxazolidinones with Aldehydes

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Total synthesis of RK-397

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12 December 2020

based on heuristic

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Histone deacetylase inhibitors

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18205373

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12 December 2020

based on heuristic

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IMDA-radical cyclization approach to (+)-himbacine

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PubMed

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12 December 2020

based on heuristic

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Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18205373

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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5646989

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Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228) (Q24633204)

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Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228) (Q24633204)

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