NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents (Q24630525)

1

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Tarek Z Deeb

2

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Joshua A Walker

3

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Paul A Davies

4

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Stephen J Moss

Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation

5

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language of work or name

English

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publication date

June 2011

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published in

Nature Neuroscience

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volume

14

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issue

6

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page(s)

736-43

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cites work

1 reference

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Neuroprotection for ischemic stroke: past, present and future

7 April 2017

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BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

7 April 2017

1 reference

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Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

7 April 2017

1 reference

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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

7 April 2017

1 reference

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Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform

7 April 2017

1 reference

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Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury

7 April 2017

1 reference

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Excitatory actions of gaba during development: the nature of the nurture

7 April 2017

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The structure and regulation of protein phosphatases

7 April 2017

1 reference

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Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.

7 April 2017

1 reference

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Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

27 September 2017

1 reference

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Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2.

27 September 2017

1 reference

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Sites of regulated phosphorylation that control K-Cl cotransporter activity

27 September 2017

1 reference

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Cation-chloride cotransporters and neuronal function

27 September 2017

1 reference

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Chloride regulation in the pain pathway

27 September 2017

1 reference

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The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury

27 September 2017

1 reference

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Roles of the cation-chloride cotransporters in neurological disease.

27 September 2017

1 reference

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Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients

27 September 2017

1 reference

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Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy

27 September 2017

1 reference

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Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.

27 September 2017

1 reference

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Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.

27 September 2017

1 reference

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WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

27 September 2017

1 reference

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Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

27 September 2017

1 reference

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Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

27 September 2017

1 reference

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On the origin of interictal activity in human temporal lobe epilepsy in vitro.

27 September 2017

1 reference

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Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains.

27 September 2017

1 reference

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Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Down-regulation of K+ -Cl- co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Predictors of seizure onset after intracerebral hemorrhage and the role of long-term antiepileptic therapy.

28 November 2018

1 reference

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Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Sustained depolarizing shift of the GABA reversal potential by glutamate receptor activation in hippocampal neurons

28 November 2018

1 reference

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Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Induction of NMDA and GABAA receptor-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Glutamate, NMDA, and AMPA induced changes in extracellular space volume and tortuosity in the rat spinal cord.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Is the underlying cause of epilepsy a major prognostic factor for recurrence?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Activity-dependent disinhibition. II. Effects of extracellular potassium, furosemide, and membrane potential on ECl- in hippocampal CA3 neurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3102766

Seizures after stroke: a prospective multicenter study

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21532577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.2806

1 reference

Dimensions Publication ID

1569741

1027451514

0 references

1569741

1 reference

1 reference

1 reference