Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue (Q24630403)

14

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Nunzio Bottini

15

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Edoardo Fiorillo

1

object named as

Edoardo Fiorillo

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author name string

Valeria Orrú

2

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Stephanie M Stanford

3

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Yingge Liu

4

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Novella Rapini

6

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Aaron D Schenone

7

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Patrizia Saccucci

8

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Lucia G Delogu

9

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Federica Angelini

10

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Maria Luisa Manca Bitti

11

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Christian Schmedt

12

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Andrew C Chan

Journal of Biological Chemistry

13

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language of work or name

English

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publication date

20 August 2010

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published in

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volume

285

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issue

34

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page(s)

26506-18

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cites work

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

1 reference

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

7 April 2017

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Identification of substrates of human protein-tyrosine phosphatase PTPN22

7 April 2017

1 reference

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Multiple sequence alignment with the Clustal series of programs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

7 April 2017

1 reference

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Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

7 April 2017

1 reference

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Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

7 April 2017

1 reference

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Role of PTPN22 in type 1 diabetes and other autoimmune diseases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

7 April 2017

1 reference

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

PTPN22: setting thresholds for autoimmunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Removal of C-terminal SRC kinase from the immune synapse by a new binding protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Ribonuclease S-peptide as a carrier in fusion proteins.

27 September 2017

1 reference

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Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Identification of a putative regulator of early T cell activation genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924087

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

Csk controls antigen receptor-mediated development and selection of T-lineage cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

Expression of human PTPN22 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.111104

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20538612

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20538612