Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease (Q24629583)

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B Lee

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J J Schott

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D W Benson

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C E Seidman

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S Izumo

Journal of Clinical Investigation

7

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language of work or name

English

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publication date

July 2000

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published in

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volume

106

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page(s)

299-308

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issue

2

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cites work

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

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Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5

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Congenital heart disease caused by mutations in the transcription factor NKX2-5

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Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand

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The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression

7 April 2017

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CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway

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Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements

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Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

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Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain

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27 September 2017

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27 September 2017

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27 September 2017

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Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia.

30 May 2018

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Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.

30 May 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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12 December 2020

inferred from PubMed ID database lookup

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inferred from PubMed ID database lookup

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inferred from PubMed ID database lookup

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7 January 2021