Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273 (Q24626912)

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21 January 2020

title

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273 (English)

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21 January 2020

0 references

1 reference

4

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21 January 2020

9

Craig W Lindsley

1 reference

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21 January 2020

8

P Jeffrey Conn

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21 January 2020

2

Alice L Rodriguez

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21 January 2020

5

Daryl Venable

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21 January 2020

1

Darren W Engers

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21 January 2020

7

Gary A Sulikowski

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21 January 2020

author name string

Richard Williams

series ordinal

3

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21 January 2020

Oluwatomi Oluwatola

series ordinal

6

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21 January 2020

language of work or name

English

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publication date

1 April 2009

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21 January 2020

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21 January 2020

volume

4

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21 January 2020

issue

4

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21 January 2020

page(s)

505-511

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Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects

21 January 2020

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7 April 2017

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

7 April 2017

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Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

27 September 2017

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Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes

27 September 2017

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

27 September 2017

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Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

27 September 2017

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Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

27 September 2017

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

27 September 2017

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EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

27 September 2017

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

27 September 2017

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Direct and indirect modulation of the N-methyl D-aspartate receptor

27 September 2017

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NMDA receptor hypofunction model of schizophrenia

27 September 2017

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

27 September 2017

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Mechanisms of typical and atypical antipsychotic drug action in relation to dopamine and NMDA receptor hypofunction hypotheses of schizophrenia

27 September 2017

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Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia

27 September 2017

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27 September 2017

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High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia

21 January 2018

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The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia.

28 November 2018

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Imaging D2 receptor occupancy by endogenous dopamine in humans.

28 November 2018

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Clozapine--a serotonin antagonist?

28 November 2018

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Schizophrenia: the fundamental questions

28 November 2018

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12 December 2020

Glutamate receptor expression in schizophrenic brain

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12 December 2020

Preliminary investigation of high-dose oral glycine on serum levels and negative symptoms in schizophrenia: an open-label trial

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12 December 2020

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia

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Diagnosis, Prevention and Treatment of Aspirin-Induced Asthma and Rhinitis

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/CMDC.200800357

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19197923%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19197923%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference