2-Aminothiazoles as therapeutic leads for prion diseases (Q24618566)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21247166%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

2-Aminothiazoles as therapeutic leads for prion diseases (English)

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20 January 2020

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Alejandra Gallardo-Godoy

1

1 reference

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20 January 2020

Adam R Renslo

6

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20 January 2020

5

Stanley B Prusiner

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20 January 2020

author name string

Joel Gever

2

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20 January 2020

Kimberly L Fife

3

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20 January 2020

B Michael Silber

4

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20 January 2020

language of work or name

English

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publication date

19 January 2011

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Journal of Medicinal Chemistry

20 January 2020

published in

1 reference

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20 January 2020

volume

54

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20 January 2020

issue

4

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20 January 2020

page(s)

1010-1021

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

20 January 2020

cites work

1 reference

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7 April 2017

1 reference

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Discovery of 2-aminothiazoles as potent antiprion compounds

7 April 2017

1 reference

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Chemical induction of misfolded prion protein conformers in cell culture.

27 September 2017

1 reference

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Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease

27 September 2017

1 reference

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Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner

27 September 2017

1 reference

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New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation

27 September 2017

1 reference

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Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics

27 September 2017

1 reference

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Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics

27 September 2017

1 reference

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Structure-brain exposure relationships

27 September 2017

1 reference

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A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations

27 September 2017

1 reference

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Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells

27 September 2017

1 reference

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A systematic review of prion therapeutics in experimental models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Cationic polysaccharides as antiprion agents.

27 September 2017

1 reference

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Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Cell cultures as tools in biopharmacy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Mimicking dominant negative inhibition of prion replication through structure-based drug design

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Characterization of scrapie infection in mouse neuroblastoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041857

Simvastatin treatment prolongs the survival of scrapie-infected mice.

30 May 2018

1 reference

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Neurodegeneration. Could they all be prion diseases?

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21247166

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM101250Y

2 references

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20 January 2020

1 reference

2 references

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20 January 2020

2 references