Latent reservoirs of HIV: obstacles to the eradication of virus (Q24615570)

PubMed publication ID

19 October 2023

T W Chun

1

T W

Chun

1 reference

PubMed publication ID

10500107

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

publication date

28 September 1999

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language of work or name

English

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published in

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volume

96

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issue

20

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page(s)

10958-61

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cites work

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Viral dynamics in human immunodeficiency virus type 1 infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Decay characteristics of HIV-1-infected compartments during combination therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Restoration of the immune system with anti-retroviral therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Increasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies. Tuscany AIDS Study Group

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Combination antiretroviral therapy and recent declines in AIDS incidence and mortality

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Early establishment of a pool of latently infected, resting CD4 + T cells during primary HIV-1 infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

A National Tissue Bank to Track HIV Eradication and Immune Reconstitution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Recent dramatic decrease in AIDS cases and HIV-related deaths contrasts with stable rate of new HIV-positive patients detected in Lyon, France, from 1988 to 1997.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Outpatient Continuous Intravenous Interleukin‐2 or Subcutaneous, Polyethylene Glycol‐Modified Interleukin‐2 in Human Immunodeficiency Virus‐Infected Patients: A Randomized, Controlled, Multicenter Study

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

HIV/AIDS in 1998—Gaining the Upper Hand?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Pathways of T‐cell regeneration in mice and humans: implications for bone marrow transplantation and immmunotherapy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Exploring How to Get at--and Eradicate--Hidden HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Toward HIV Eradication or Remission: The Tasks Ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

HIV-1 replication in patients with undetectable plasma virus receiving HAART. Highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Effects of IL-2 therapy in asymptomatic HIV-infected individuals on proliferative responses to mitogens, recall antigens and HIV-related antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Overshoot of HIV-1 viraemia after early discontinuation of antiretroviral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Rate of HIV-1 RNA rebound upon stopping antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

A primer on HIV type 1-specific immune function and REMUNE

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34225

Changes in thymic function with age and during the treatment of HIV infection

28 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.10958

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

21 January 2018

1 reference

12 December 2020

Cellular and Anatomical Reservoirs of HIV-1 in Patients Receiving Potent Antiretroviral Combination Therapy

1 reference

12 December 2020

HIV and AIDS in the Asia-Pacific region: an epidemiological overview

1 reference

12 December 2020

Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1

1 reference

12 December 2020

Comparison between subcutaneous and intravenous interleukin‐2 treatment in HIV disease

1 reference

12 December 2020

Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy

1 reference

12 December 2020

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1 reference

12 December 2020

Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease

1 reference

12 December 2020

Interleukin-2 in combination with zidovudine and didanosine is able to maintain high levels of CD4 cells and undetectable HIV viraemia

1 reference

12 December 2020

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1 reference

12 December 2020

release_ekpvdv4mrbf6nljz2yjf5ninui

Identifiers

DOI

10.1073/PNAS.96.20.10958

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ADS bibcode

1999PNAS...9610958C

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Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ekpvdv4mrbf6nljz2yjf5ninui

24 November 2022