The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats (Q24603020)

22 June 2017

The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats (English)

1 reference

22 June 2017

Michele Bellesi

1

0 references

author name string

Fiorenzo Conti

series ordinal

2

1 reference

PubMed ID

20072121

22 June 2017

language of work or name

English

0 references

publication date

13 January 2010

1 reference

22 June 2017

Neuropsychopharmacology

1 reference

22 June 2017

35

1 reference

22 June 2017

1253-1260

1 reference

22 June 2017

6

1 reference

Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

22 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Clozapine reduces GLT-1 expression and glutamate uptake in astrocyte cultures

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Mouse genetic models for prepulse inhibition: an early review

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

7 April 2017

1 reference

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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

7 April 2017

1 reference

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7 April 2017

1 reference

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Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Gating and habituation of the startle reflex in schizophrenic patients

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

7 April 2017

1 reference

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Receptor actions of synaptically released glutamate: the role of transporters on the scale from nanometers to microns

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility

27 September 2017

1 reference

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Shared gene expression alterations in schizophrenia and bipolar disorder

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268.

27 September 2017

1 reference

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Glutamate transporters: confining runaway excitation by shaping synaptic transmission

27 September 2017

1 reference

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EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention

27 September 2017

1 reference

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Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia

27 September 2017

1 reference

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Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia

27 September 2017

1 reference

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Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement

27 September 2017

1 reference

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Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations

27 September 2017

1 reference

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The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients

27 September 2017

1 reference

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Pathophysiologically based treatment interventions in schizophrenia

27 September 2017

1 reference

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Metabotropic glutamate receptors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Housekeeping proteins: a preliminary study illustrating some limitations as useful references in protein expression studies.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Daily variations in ceftriaxone pharmacokinetics in rats

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Perisynaptic asymmetry of glia: new insights into glutamate signalling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Shaping excitation at glutamatergic synapses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Sensorimotor gating and schizophrenia. Human and animal model studies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Up-regulation of GLT-1 severely impairs LTD at mossy fibre--CA3 synapses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Effects of sustained phencyclidine exposure on sensorimotor gating of startle in rats

30 May 2018

1 reference

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Activation of AMPA, kainate, and metabotropic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055342

Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation.

30 May 2018

1 reference

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Purification and reconstitution of the sodium- and potassium-coupled glutamate transport glycoprotein from rat brain.

30 May 2018

1 reference

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The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice.

30 May 2018

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Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patients

21 January 2018

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GLT-1 down-regulation induced by clozapine in rat frontal cortex is associated with synaptophysin up-regulation.

21 January 2018

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Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation.

21 January 2018

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Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats

21 January 2018

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On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia

21 January 2018

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A broad view of glutamate spillover

21 January 2018

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GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine.

21 January 2018

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Metabotropic glutamate receptor agonists for schizophrenia

21 January 2018

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Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat.

21 January 2018

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Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics

21 January 2018

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Synaptic localization of GLT-1a in the rat somatic sensory cortex

21 January 2018

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GLT-1 up-regulation enhances the effect of PCP on prepulse inhibition of the startle reflex in adult rats

21 January 2018

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Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1.

21 January 2018

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Light microscopic identification and immunocytochemical characterization of glutamatergic synapses in brain sections

21 January 2018

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The glial glutamate transporter GLT-1 is localized both in the vicinity of and at distance from axon terminals in the rat cerebral cortex

21 January 2018

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Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors.

21 January 2018

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Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia

21 January 2018

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The effect of auditory and visual stimulation on the skin potential response of schizophrenics.

21 January 2018

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Schizophrenia: the fundamental questions

21 January 2018

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Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.

21 January 2018

1 reference

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An evaluation of synapse independence.

28 November 2018

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Glutamate spillover suppresses inhibition by activating presynaptic mGluRs

28 November 2018

1 reference

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Schizophrenia and the mechanisms of conscious integration

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20072121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20072121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Disorders of attention and perception in early schizophrenia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20072121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NPP.2009.225

1 reference

PubMed ID

20072121

Dimensions Publication ID

22 June 2017

0 references

0 references

1 reference

PubMed ID

20072121