The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems (Q24596433)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0052614

(Z)-2-hydroxy-3-aminoperacrylic acid

1 reference

(Z)-2-methylureidoperacrylic acid

ChEBI release 2020-05-28

ChEBI ID

63250

1 reference

ChEBI release 2020-05-28

5

Sydney Kustu

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author name string

Kwang-Seo Kim

1

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Jeffrey G Pelton

2

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William B Inwood

3

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Ulla Andersen

4

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David E Wemmer

Catalysis of a flavoenzyme-mediated amide hydrolysis

6

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language of work or name

English

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publication date

August 2010

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published in

Journal of Bacteriology

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volume

192

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issue

16

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page(s)

4089-102

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cites work

1 reference

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24 March 2017

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Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

24 March 2017

1 reference

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A previously undescribed pathway for pyrimidine catabolism

24 March 2017

1 reference

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Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis

24 March 2017

1 reference

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An mRNA structure that controls gene expression by binding FMN

24 March 2017

1 reference

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Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily

24 March 2017

1 reference

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Crystal structure of a minimal nitroreductase, ydjA, from Escherichia coli K12 with and without FMN cofactor

24 March 2017

1 reference

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The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family

24 March 2017

1 reference

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A test case for structure-based functional assignment: The 1.2 Å crystal structure of the yjgF gene product from Escherichia coli

24 March 2017

1 reference

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1.8 A crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins

24 March 2017

1 reference

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Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution

24 March 2017

1 reference

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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

24 March 2017

1 reference

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1H, 13C and 15N chemical shift referencing in biomolecular NMR

24 March 2017

1 reference

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

24 March 2017

1 reference

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A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.

24 March 2017

1 reference

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Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C).

24 March 2017

1 reference

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YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium

24 March 2017

1 reference

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Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress

24 March 2017

1 reference

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Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes

24 March 2017

1 reference

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Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria

24 March 2017

1 reference

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Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism

24 March 2017

1 reference

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Characterization of plant beta-ureidopropionase and functional overexpression in Escherichia coli

24 March 2017

1 reference

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The chemical and biological versatility of riboflavin

24 March 2017

1 reference

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Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli

24 March 2017

1 reference

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Uracil Catabolism by Escherichia coli K12S

24 March 2017

1 reference

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Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis

24 March 2017

1 reference

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Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

24 March 2017

1 reference

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Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research

7 April 2017

1 reference

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Epistatic effects of the protease/chaperone HflB on some damaged forms of the Escherichia coli ammonium channel AmtB.

7 April 2017

1 reference

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The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions.

27 September 2017

1 reference

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Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase

27 September 2017

1 reference

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RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

A hidden metabolic pathway exposed

27 September 2017

1 reference

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Sulfur and nitrogen limitation in Escherichia coli K-12: specific homeostatic responses

27 September 2017

1 reference

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Physiological studies of Escherichia coli strain MG1655: growth defects and apparent cross-regulation of gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Sensing Small Molecules by Nascent RNA

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

'New uses for an Old Enzyme'--the Old Yellow Enzyme family of flavoenzymes

27 September 2017

1 reference

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IS186 insertion at a hot spot in the lon promoter as a basis for lon protease deficiency of Escherichia coli B: identification of a consensus target sequence for IS186 transposition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Phylogenetic characterization of novel transport protein families revealed by genome analyses

27 September 2017

1 reference

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Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Activation of molecular oxygen by flavins and flavoproteins.

27 September 2017

1 reference

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A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

27 September 2017

Formaldehyde fixation

1 reference

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Metabolic mayhem caused by 2-ketoacid imbalances

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Degradation of purines and pyrimidines by microorganisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Occurrence of glutathione in bacteria

27 September 2017

1 reference

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Charges of nicotinamide adenine nucleotides and adenylate energy charge as regulatory parameters of the metabolism in Escherichia coli

27 September 2017

1 reference

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The uncharacterized transcription factor YdhM is the regulator of the nemA gene, encoding N-ethylmaleimide reductase

27 September 2017

1 reference

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Chemotaxis of Escherichia coli to pyrimidines: a new role for the signal transducer tap.

30 May 2018

1 reference

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Purification and characterization of a novel enzyme, N-carbamoylsarcosine amidohydrolase, from Pseudomonas putida 77.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916427

Mapping protein–protein interaction by 13C′-detected heteronuclear NMR spectroscopy

30 May 2018

1 reference

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Osamu Hayaishi: pioneer first of the oxygenases, then the molecular basis of sleep and throughout a great statesman of science

28 November 2018

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MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20400551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Properties and regulation of pyrimidine catabolism in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20400551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanistic studies on cyclohexanone oxygenase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20400551