Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase (Q24563901)

2

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Hiroaki Terato

3

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Eiji Ohmae

4

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Shunsuke Izumi

5

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Katsuo Katayanagi

6

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Hiroshi Ide

The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models

7

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language of work or name

English

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publication date

2004

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published in

Nucleic Acids Research

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volume

32

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issue

17

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page(s)

5291-302

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cites work

1 reference

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SWISS-MODEL: An automated protein homology-modeling server

24 March 2017

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Mammalian 5-Formyluracil−DNA Glycosylase. 2. Role of SMUG1 Uracil−DNA Glycosylase in Repair of 5-Formyluracil and Other Oxidized and Deaminated Base Lesions

24 March 2017

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hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

24 March 2017

1 reference

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

24 March 2017

1 reference

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The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

24 March 2017

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Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

24 March 2017

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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

24 March 2017

1 reference

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Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

24 March 2017

1 reference

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Instability and decay of the primary structure of DNA

24 March 2017

1 reference

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Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1

24 March 2017

1 reference

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Crystal structure of a thwarted mismatch glycosylase DNA repair complex

24 March 2017

1 reference

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

24 March 2017

1 reference

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The structural basis of specific base-excision repair by uracil-DNA glycosylase

24 March 2017

1 reference

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

24 March 2017

1 reference

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Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions

24 March 2017

1 reference

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Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

24 March 2017

1 reference

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Structure and function in the uracil-DNA glycosylase superfamily

24 March 2017

1 reference

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Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

24 March 2017

1 reference

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Mammalian 5-formyluracil-DNA glycosylase. 1. Identification and characterization of a novel activity that releases 5-formyluracil from DNA

24 March 2017

1 reference

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Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

24 March 2017

1 reference

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Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

24 March 2017

1 reference

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7 April 2017

DNA replication fidelity

1 reference

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Human DNA glycosylases involved in the repair of oxidatively damaged DNA.

7 April 2017

1 reference

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The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.

27 September 2017

1 reference

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Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases

27 September 2017

1 reference

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Structural characterization of the Fpg family of DNA glycosylases

27 September 2017

1 reference

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The enigma of endonuclease VIII.

27 September 2017

1 reference

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The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications

27 September 2017

1 reference

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27 September 2017

DNA damage and repair

1 reference

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Biological consequences of free radical-damaged DNA bases.

27 September 2017

1 reference

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A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site

27 September 2017

1 reference

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Recent progress in the biology, chemistry and structural biology of DNA glycosylases

27 September 2017

1 reference

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Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Enzymatic repair of 5-formyluracil. II. Mismatch formation between 5-formyluracil and guanine during dna replication and its recognition by two proteins involved in base excision repair (AlkA) and mismatch repair (MutS).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Substrate and mispairing properties of 5-formyl-2'-deoxyuridine 5'-triphosphate assessed by in vitro DNA polymerase reactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Hydroxymethyluracil DNA glycosylase in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Alternative nucleotide incision repair pathway for oxidative DNA damage

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Effects of five-tryptophan mutations on structure, stability and function of Escherichia coli dihydrofolate reductase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Comparison of substrate specificities of Escherichia coli endonuclease III and its mouse homologue (mNTH1) using defined oligonucleotide substrates.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Purification and characterization of 5-hydroxymethyluracil-DNA glycosylase from calf thymus. Its possible role in the maintenance of methylated cytosine residues

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521670

Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: evidence for an oxocarbenium ion-uracil anion intermediate

28 November 2018

1 reference

12 December 2020

Enzymatic processing of radiation-induced free radical damage in DNA

1 reference

12 December 2020

Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides

1 reference

12 December 2020

Enzymatic repair of 5-formyluracil. I. Excision of 5-formyluracil site-specifically incorporated into oligonucleotide substrates by alka protein (Escherichia coli 3-methyladenine DNA glycosylase II)

1 reference

12 December 2020

X-ray analyses of DNA dodecamers containing 2'-deoxy-5-formyluridine

1 reference

12 December 2020

5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function

1 reference

12 December 2020

Effects of point mutations at the flexible loop glycine-67 of Escherichia coli dihydrofolate reductase on its stability and function

1 reference

12 December 2020