The remarkable transport mechanism of P-glycoprotein: a multidrug transporter (Q24547974)

21 June 2017

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title

The remarkable transport mechanism of P-glycoprotein: a multidrug transporter (English)

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21 June 2017

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Marwan K Al-Shawi

1

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21 June 2017

Hiroshi Omote

series ordinal

2

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21 June 2017

language of work or name

English

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publication date

1 December 2005

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Journal of Bioenergetics and Biomembranes

21 June 2017

published in

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21 June 2017

volume

37

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21 June 2017

issue

6

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21 June 2017

page(s)

489-496

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Crystal structure of the ATP-binding subunit of an ABC transporter

21 June 2017

cites work

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Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells

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Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

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27 September 2017

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Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein

27 September 2017

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

27 September 2017

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Use of chemical chaperones in the yeast Saccharomyces cerevisiae to enhance heterologous membrane protein expression: high-yield expression and purification of human P-glycoprotein

27 September 2017

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27 September 2017

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Rotational coupling in the F0F1 ATP synthase

27 September 2017

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

27 September 2017

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

27 September 2017

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Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

27 September 2017

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

27 September 2017

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Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

27 September 2017

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P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

27 September 2017

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Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

27 September 2017

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27 September 2017

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The catalytic cycle of P-glycoprotein

27 September 2017

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ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells

27 September 2017

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Reconstitution of Drug Transport by Purified P-glycoprotein

27 September 2017

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27 September 2017

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Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein

27 September 2017

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Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

27 September 2017

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An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

27 September 2017

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Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

30 May 2018

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Identification of two different states of P-glycoprotein in its catalytic cycle: role of the linker region in the transition between these two states

30 May 2018

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Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1).

30 May 2018

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The P-glycoprotein efflux pump: how does it transport drugs?

30 May 2018

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Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

30 May 2018

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Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

30 May 2018

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Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells.

30 May 2018

1 reference

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P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

30 May 2018

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Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein

30 May 2018

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A new dimer interface for an ABC transporter

28 November 2018

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Expression of functional multidrug-resistance protein 1 in Saccharomyces cerevisiae: effects of N- and C-terminal affinity tags

28 November 2018

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The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

28 November 2018

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Structure-activity relationship of P-glycoprotein substrates and modifiers.

28 November 2018

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Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

28 November 2018

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The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

28 November 2018

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A general pattern for substrate recognition by P-glycoprotein.

28 November 2018

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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

28 November 2018

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12 December 2020

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

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12 December 2020

The importance of a nitrogen atom in modulators of multidrug resistance

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12 December 2020

Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast

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12 December 2020

Overexpression and purification of the vanilloid receptor in yeast (Saccharomyces cerevisiae)

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12 December 2020

10.1007/S10863-005-9497-5

Identifiers

DOI

1 reference

Dimensions Publication ID

21 June 2017

1007115544

0 references

OpenCitations bibliographic resource ID

2061479

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2061479

1 reference