N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains (Q24523689)

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W C Vass

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A G Papageorge

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P H Anborgh

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D R Lowy

Molecular and Cellular Biology

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language of work or name

English

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publication date

February 1998

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published in

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volume

18

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page(s)

771-8

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issue

2

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cites work

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

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27 September 2017

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

27 September 2017

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27 September 2017

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27 September 2017

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The Son of sevenless Gene Product: a Putative Activator of Ras

27 September 2017

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The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.

27 September 2017

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27 September 2017

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The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

27 September 2017

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Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

27 September 2017

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The Grb2 binding domain of mSos1 is not required for downstream signal transduction

27 September 2017

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27 September 2017

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Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

27 September 2017

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Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless

30 May 2018

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Inhibition of cell growth by lovastatin is independent of ras function

30 May 2018

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

30 May 2018

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Mechanistic aspects of signaling through Ras in NIH 3T3 cells

30 May 2018

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30 May 2018

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Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia

29 November 2018

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

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PubMed

https://pubmed.ncbi.nlm.nih.gov/9447973