Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting (Q24338925)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612608%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting (English)

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10 March 2020

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Flotillin 1

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Flotillin 2

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negative regulation of amyloid precursor protein catabolic process

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author

Ritva Tikkanen

4

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10 March 2020

author name string

Bincy A John

1

1 reference

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10 March 2020

Melanie Meister

2

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10 March 2020

Antje Banning

3

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10 March 2020

language of work or name

English

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publication date

6 March 2014

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10 March 2020

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10 March 2020

volume

281

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10 March 2020

issue

8

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10 March 2020

page(s)

2074-2087

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Trafficking and proteolytic processing of APP

10 March 2020

cites work

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

21 January 2018

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

21 January 2018

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The GGA proteins: adaptors on the move

21 January 2018

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The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

21 January 2018

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Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

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Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

21 January 2018

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Functional aspects of membrane association of reggie/flotillin proteins

21 January 2018

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Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation

21 January 2018

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Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

21 January 2018

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Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.

21 January 2018

1 reference

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Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton

21 January 2018

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Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

21 January 2018

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Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.

21 January 2018

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Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

21 January 2018

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Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment

21 January 2018

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Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.

21 January 2018

1 reference

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Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

21 January 2018

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Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

21 January 2018

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Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

21 January 2018

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Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis

21 January 2018

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The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

21 January 2018

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Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue

21 January 2018

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Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology.

21 January 2018

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Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain

21 January 2018

1 reference

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Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes

21 January 2018

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

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The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice.

21 January 2018

1 reference

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BACE1 interacts with lipid raft proteins

21 January 2018

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Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

21 January 2018

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Protein detection using proximity-dependent DNA ligation assays.

21 January 2018

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

21 January 2018

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Digital quantification using amplified single-molecule detection.

21 January 2018

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GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

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Ubiquitin regulates GGA3-mediated degradation of BACE1

21 January 2018

1 reference

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Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking

21 January 2018

1 reference

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Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

21 January 2018

1 reference

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Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2

21 January 2018

1 reference

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Interplay between toxin transport and flotillin localization

21 January 2018

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

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A guided tour into subcellular colocalization analysis in light microscopy

21 January 2018

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Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12763

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1111/FEBS.12763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612608%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference