Inhibition of GLI1 gene activation by Patched1 (Q24338436)

negative regulation of osteoblast differentiation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

3

Matthias Lauth

Matthias

Lauth

1 reference

20 October 2023

7

Rune Toftgård

Rune

Toftgård

1 reference

20 October 2023

Fahimeh Rahnama

1

Fahimeh

Rahnama

1 reference

20 October 2023

Takashi Shimokawa

2

Takashi

Shimokawa

1 reference

20 October 2023

Csaba Finta

4

Csaba

Finta

1 reference

20 October 2023

Priit Kogerman

5

Priit

Kogerman

1 reference

20 October 2023

Stephan Teglund

6

Stephan

Teglund

1 reference

20 October 2023

Peter G Zaphiropoulos

8

Peter G

Distinct roles of PTCH2 splice variants in Hedgehog signalling

Zaphiropoulos

1 reference

20 October 2023

language of work or name

English

0 references

publication date

15 February 2006

0 references

published in

Biochemical Journal

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volume

394

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page(s)

19-26

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issue

Pt 1

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Intergenic mRNA molecules resulting from trans-splicing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Characterization of the physical interaction of Gli proteins with SUFU proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Patched acts catalytically to suppress the activity of Smoothened

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Gli1 can rescue the in vivo function of Gli2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Gli proteins encode context-dependent positive and negative functions: implications for development and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Developmental roles and clinical significance of hedgehog signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Hedgehog signaling: Costal-2 bridges the transduction gap.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Biochemical evidence that patched is the Hedgehog receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Role of the Drosophila patched gene in positional signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

The GLI gene is a member of the Kruppel family of zinc finger proteins.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1385998