Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity (Q24336042)

Serine/threonine kinase 3

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Ras association domain family member 2

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Ras association (RalGDS/AF-6) domain family member 2

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Serine/threonine kinase 4

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Serine/threonine kinase 3

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Biochemical and Biophysical Research Communications

Dae-Sik Lim

4

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author name string

Hoogeun Song

series ordinal

1

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Sangphil Oh

series ordinal

2

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Hyun Jung Oh

series ordinal

3

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language of work or name

English

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publication date

1 January 2010

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published in

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volume

391

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page(s)

969-73

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issue

1

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

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Identification of a novel Ras-regulated proapoptotic pathway

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Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

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RASSF2 associates with and stabilizes the proapoptotic kinase MST2

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RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer

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MST1-JNK promotes apoptosis via caspase-dependent and independent pathways

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The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer

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The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

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RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

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Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation

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Regulation of neuronal cell death by MST1-FOXO1 signaling

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RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis

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Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.

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MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability

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Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.

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Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse

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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

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Dynamic FoxO transcription factors

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