The regulation of the cardiac potassium channel (HERG) by caveolin-1 (Q24324091)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903609

Potassium voltage-gated channel subfamily H member 2

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GOA release 2020-03-11

Caveolin 1

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GOA release 2020-03-11

scaffold protein binding

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GOA release 2020-03-11

author name string

Jijin Lin

1

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Shuguang Lin

2

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Patrick C Choy

3

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Xiuzhang Shen

4

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Chunyu Deng

5

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Sujuan Kuang

6

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Jun Wu

7

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Wencan Xu

Biochemistry and Cell Biology

8

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language of work or name

English

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publication date

October 2008

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published in

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volume

86

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page(s)

405-15

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issue

5

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cites work

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

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Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains

21 January 2018

1 reference

Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K(+) channel.

21 January 2018

1 reference

Sudden death associated with short-QT syndrome linked to mutations in HERG.

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A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase

21 January 2018

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Regulation of an ERG K+ current by Src tyrosine kinase

21 January 2018

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Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization

21 January 2018

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Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities

21 January 2018

1 reference

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

21 January 2018

1 reference

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 January 2018

1 reference

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

21 January 2018

1 reference

Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

21 January 2018

1 reference

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

21 January 2018

1 reference

Double barrel shotgun scanning of the caveolin-1 scaffolding domain

21 January 2018

1 reference

Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10

21 January 2018

1 reference

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

21 January 2018

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Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.

21 January 2018

1 reference

Alpha1-adrenergic receptor signaling is localized to caveolae in neonatal rat cardiomyocytes

21 January 2018

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Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default

21 January 2018

1 reference

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

Caveolae: from cell biology to animal physiology

21 January 2018

1 reference

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.

21 January 2018

1 reference

Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels

21 January 2018

1 reference

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

The use of time-resolved fluorescence imaging in the study of protein kinase C localisation in cells

21 January 2018

1 reference

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.

21 January 2018

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HERG, a human inward rectifier in the voltage-gated potassium channel family

21 January 2018

1 reference

Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells.

21 January 2018

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Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes

21 January 2018

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Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

21 January 2018

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Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels

21 January 2018

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Cyclic AMP regulates the HERG K(+) channel by dual pathways

21 January 2018

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7 January 2021

Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A

1 reference

7 January 2021

Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway

1 reference

7 January 2021

Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A

1 reference

7 January 2021

Activated protein kinase C isoforms target to cardiomyocyte caveolae : stimulation of local protein phosphorylation

1 reference

7 January 2021