The human steroid hydroxylases CYP1B1 and CYP11B2 (Q24321759)

cytochrome P450 family 11 subfamily B member 1

Europe PubMed Central

title

The human steroid hydroxylases CYP1B1 and CYP11B2 (English)

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main subject

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GOA release 2020-03-11

immune response

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Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli.

GOA release 2020-03-11

1

Matthias Bureik

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Rita Bernhardt

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3

object named as

Rita Bernhardt

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author name string

Matthias Bureik

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1

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Michael Lisurek

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2

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language of work or name

English

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publication date

October 2002

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published in

Biological Chemistry

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volume

383

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page(s)

1537-51

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issue

10

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cites work

1 reference

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The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme

21 January 2018

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Specific aspects of electron transfer from adrenodoxin to cytochromes p450scc and p45011beta.

21 January 2018

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Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2-specific ones

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Aldosterone and myocardial fibrosis in heart failure

21 January 2018

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Molecular cloning and functional expression of the cytochrome P450 11B-hydroxylase of the guinea pig.

21 January 2018

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Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity

21 January 2018

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Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.

21 January 2018

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Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells

21 January 2018

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Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11)

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex

21 January 2018

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Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology

21 January 2018

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Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids

21 January 2018

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11 beta-hydroxylase activity in recombinant yeast mitochondria. In vivo conversion of 11-deoxycortisol to hydrocortisone.

21 January 2018

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Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells

21 January 2018

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Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures

21 January 2018

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Genetics of the mineralocorticoid system in primary hypertension

21 January 2018

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Effects of 18-Hydroxylated Steroids on Corticosteroid Production by Human Aldosterone Synthase and 11 -Hydroxylase

21 January 2018

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Adrenodoxin: structure, stability, and electron transfer properties

21 January 2018

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Unequal Crossing-Over between Aldosterone Synthase and 11 -Hydroxylase Genes Causes Congenital Adrenal Hyperplasia

21 January 2018

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Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Heterogeneity of adrenocortical ferredoxin

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Kinetic studies on bovine cytochrome p45011 beta catalyzing successive reactions from deoxycorticosterone to aldosterone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Cloning of cDNA and genomic DNA for human cytochrome P-45011 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Molecular mechanisms of human hypertension

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Induction of cardiac fibrosis by aldosterone

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

21 January 2018

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Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta)

21 January 2018

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Novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.

21 January 2018

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Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production

21 January 2018

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Functional expression of the cDNAs encoding rat 11 beta-hydroxylase [cytochrome P450(11 beta)] and aldosterone synthase [cytochrome P450(11 beta, aldo)].

21 January 2018

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Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis.

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Lipid regulation of bovine cytochrome P450(11) beta activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Spironolactone in congestive heart failure

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Medical therapy for Cushing's disease

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

A hybrid cell mapping panel for regional localization of probes to human chromosome 8

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Effect of ketoconazole on human ovarian C17,20-desmolase and aromatase

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Steroid 11 beta-hydroxylase deficiency and related disorders

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Aldosterone and the heart

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients

21 January 2018

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The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2002.174

Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: incorporation of a steroidogenic pathway into nonsteroidogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Metazoan cytochrome P450 evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Cytochrome P450: structure, function, and generation of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Pigments of rat liver microsomes

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Isolation and purification of mature bovine adrenocortical ferredoxin with an elongated carboxyl end

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Adrenal cytochrome P-45011 beta-proteoliposomes catalyzing aldosterone synthesis: preparation and characterization

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Regulation mechanism of the catalytic activity of bovine adrenal cytochrome P-450(11)beta

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Aldosterone biosynthesis by a reconstituted cytochrome P-45011 beta system

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Competition for electron transfer between cytochromes P450scc and P45011 beta in rat adrenal mitochondria

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

https://api.crossref.org/works/10.1515%2FBC.2002.174

1 reference

7 January 2021

Autosomal dominant transmission and absence of HLA linkage in dexamethasone suppressible hyperaldosteronism

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

A close family resemblance: the importance of structure in understanding cytochromes P450

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Structure/function relationship of CYP11B1 associated with Dahl's salt-resistant rats--expression of rat CYP11B1 and CYP11B2 in Escherichia coli

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Engineering a mineralocorticoid- to a glucocorticoid-synthesizing cytochrome P450

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Effect of calmodulin on aldosterone synthesis by a cytochrome P-45011 beta-reconstituted system from bovine adrenocortical mitochondria.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Synthesis of aldosterone by a reconstituted system of cytochrome P-45011 beta from bovine adrenocortical mitochondria

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Losartan inhibits the post-transcriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Phosphorylation of bovine adrenodoxin. Structural study and enzymatic activity

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021

NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.174

7 January 2021