Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt (Q24318755)

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6 January 2020

title

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt (English)

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4

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author name string

Michael J Van Kanegan

series ordinal

1

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6 January 2020

Deanna G Adams

series ordinal

2

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Brian E Wadzinski

series ordinal

3

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6 January 2020

language of work or name

English

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publication date

28 August 2005

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Journal of Biological Chemistry

6 January 2020

published in

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volume

280

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page(s)

36029-36036

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issue

43

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Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

6 January 2020

cites work

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7 January 2021

Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin.

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7 January 2021

Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B'' (delta) regulatory subunit in vitro and identification of the phosphorylation sites.

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7 January 2021

Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes

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7 January 2021

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

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7 January 2021

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

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7 January 2021

Regulation of protein kinase cascades by protein phosphatase 2A.

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Cyclin G recruits PP2A to dephosphorylate Mdm2

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7 January 2021

PKA, PKC, and the Protein Phosphatase 2A Influence HAND Factor Function

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7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

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7 January 2021

Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal

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7 January 2021

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling

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7 January 2021

Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase

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7 January 2021

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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7 January 2021

Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.

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7 January 2021

Decreased protein phosphatase 2A activity in hippocampal long-term potentiation

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7 January 2021

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

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7 January 2021

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

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7 January 2021

Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

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7 January 2021

12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells

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7 January 2021

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

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7 January 2021

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

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7 January 2021

A positive role for the PP2A catalytic subunit in Wnt signal transduction.

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7 January 2021

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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7 January 2021

Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzyme

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7 January 2021

Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A

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7 January 2021

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

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7 January 2021

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest

1 reference

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7 January 2021

The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop

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7 January 2021

A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function

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7 January 2021

Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits

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7 January 2021

Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade

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7 January 2021

The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases

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7 January 2021

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.

1 reference

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7 January 2021

A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis

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7 January 2021

Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.

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7 January 2021

Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin

1 reference

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7 January 2021

Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors

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7 January 2021

Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival.

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7 January 2021

Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A

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7 January 2021

The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases

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7 January 2021

Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'.

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7 January 2021

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

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7 January 2021

Regulation of Raf-1 activation and signalling by dephosphorylation

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7 January 2021

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

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7 January 2021

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

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7 January 2021

A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

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7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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7 January 2021

Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha

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7 January 2021

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster

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https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

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https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

Functional diversity of protein phosphatase-1, a cellular economizer and reset button

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https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506986200

7 January 2021

C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites

1 reference

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7 January 2021

Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

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7 January 2021

Identifiers

DOI

10.1074/JBC.M506986200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16129692%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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