Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades (Q24318379)

cellular response to fluid shear stress

GOA release 2020-03-11

1 reference

Polycystin 2, transient receptor potential cation channel

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Wissam A AbouAlaiwi

1

0 references

Maki Takahashi

2

0 references

Blair R Mell

3

0 references

Thomas J Jones

4

0 references

Shobha Ratnam

5

0 references

Robert J Kolb

6

0 references

Surya M Nauli

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

7

0 references

language of work or name

English

0 references

publication date

10 April 2009

0 references

published in

Circulation Research

0 references

volume

104

0 references

issue

7

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page(s)

860-9

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Cardiac defects and renal failure in mice with targeted mutations in Pkd2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Two populations of node monocilia initiate left-right asymmetry in the mouse

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

A physiological view of the primary cilium

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Polycystins and mechanosensation in renal and nodal cilia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Vascular expression of polycystin-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Primary cilia sensitize endothelial cells for fluid shear stress

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

ATP release through connexin hemichannels in corneal endothelial cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Location of mutations within the PKD2 gene influences clinical outcome.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085025

Effects of shear on endothelial cell calcium in the presence and absence of ATP

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19265036

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19265036

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Autosomal dominant polycystic kidney disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19265036