The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation (Q24317551)

1-O-(6-acetamido-6-deoxy-alpha-D-galactosyl)-N-[(15Z)-tetracos-15-enoyl]phytosphingosine

ChEBI ID

18318

1 reference

beta-D-mannosyl C32-phosphomycoketide

ChEBI ID

63080

1 reference

β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-N-acylsphingosine (R1)

ChEBI ID

61808

1 reference

1 reference

GOA release 2020-03-11

lipopeptide binding

1 reference

GOA release 2020-03-11

author name string

Louise Scharf

1

0 references

Nan-Sheng Li

2

0 references

Andrew J Hawk

3

0 references

Diana Garzón

4

0 references

Tejia Zhang

5

0 references

Lisa M Fox

6

0 references

Allison R Kazen

7

0 references

Sneha Shah

8

0 references

Esmael J Haddadian

9

0 references

Jenny E Gumperz

10

0 references

Alan Saghatelian

11

0 references

José D Faraldo-Gómez

12

0 references

Stephen C Meredith

13

0 references

Joseph A Piccirilli

14

0 references

Erin J Adams

PHENIX: a comprehensive Python-based system for macromolecular structure solution

15

0 references

language of work or name

English

0 references

publication date

14 December 2010

0 references

published in

Immunity

0 references

volume

33

0 references

issue

6

0 references

page(s)

853-62

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Molecular mechanism of lipopeptide presentation by CD1a

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

The crystal structure of human CD1b with a bound bacterial glycolipid

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

19 March 2017

Two classes of CD1 genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Phasercrystallographic software

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Coot: model-building tools for molecular graphics

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Mimicking the folding pathway to improve homology-free protein structure prediction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

TCR-mediated recognition of glycolipid CD1 complexes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1 expression on antigen-presenting cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Structures and functions of microbial lipid antigens presented by CD1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Structure and biology of self lipid antigens.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Assistance of microbial glycolipid antigen processing by CD1e

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

T cell activation by lipopeptide antigens

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Presentation of the same glycolipid by different CD1 molecules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Intracellular trafficking pathway of newly synthesized CD1b molecules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1c molecules broadly survey the endocytic system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

The crystal structure of human CD1d with and without alpha-galactosylceramide

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Molecular interaction of CD1b with lipoglycan antigens

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Predicted structural basis for CD1c presentation of mycobacterial branched polyketides and long lipopeptide antigens.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell response.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3010391

Total synthesis of enantiopure beta-D-mannosyl phosphomycoketides from Mycobacterium tuberculosis

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21167756

12 December 2020

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21167756

12 December 2020

inferred from PubMed ID database lookup

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21167756

12 December 2020

inferred from PubMed ID database lookup

Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.IMMUNI.2010.11.026

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.IMMUNI.2010.11.026

1 reference

2771014

2771014

1 reference

1 reference

1 reference