Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites (Q24316275)

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11 January 2020

title

Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites (English)

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Fructose-bisphosphatase 1

11 January 2020

main subject

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identical protein binding

GOA release 2020-03-11

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GOA release 2020-03-11

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3

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11 January 2020

author name string

Paul Hebeisen

1

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11 January 2020

Bernd Kuhn

2

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11 January 2020

Marcel Gubler

4

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11 January 2020

Walter Huber

5

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11 January 2020

Eric Kitas

6

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11 January 2020

Brigitte Schott

7

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11 January 2020

Jörg Benz

8

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11 January 2020

Catherine Joseph

9

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11 January 2020

Armin Ruf

10

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language of work or name

English

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publication date

5 July 2008

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Bioorganic & Medicinal Chemistry Letters

11 January 2020

published in

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volume

18

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issue

16

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11 January 2020

page(s)

4708-4712

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X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity

11 January 2020

cites work

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7 January 2021

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

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7 January 2021

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

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7 January 2021

Bivalent inhibitors of glutathione S-transferase: the effect of spacer length on isozyme selectivity

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7 January 2021

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

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7 January 2021

Human liver glycogen phosphorylase inhibitors bind at a new allosteric site

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Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

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7 January 2021

Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity

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7 January 2021

Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes

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7 January 2021

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

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On the attribution and additivity of binding energies

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Bivalency as a principle for proteasome inhibition

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Potent selective nonpeptidic inhibitors of human lung tryptase.

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Identifiers

DOI

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11 January 2020

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