The AMP-activated protein kinase--fuel gauge of the mammalian cell? (Q24315074)

Protein kinase AMP-activated non-catalytic subunit gamma 2

Europe PubMed Central

title

The AMP-activated protein kinase--fuel gauge of the mammalian cell? (English)

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main subject

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regulation of fatty acid oxidation

GOA release 2020-03-11

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Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

GOA release 2020-03-11

author name string

D G Hardie

series ordinal

1

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D Carling

series ordinal

2

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language of work or name

English

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publication date

1 June 1997

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published in

FEBS Journal

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volume

246

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page(s)

259-73

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issue

2

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cites work

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

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Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase

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Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

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Active and inactive protein kinases: structural basis for regulation

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Electrostatic effects in the control of glycogen phosphorylase by phosphorylation

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Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase

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Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity

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Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.

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Effect of some hormones on the rate of the triacylglycerol/fatty-acid substrate cycle in adipose tissue of the mouse in vivo

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A new puffing pattern induced by temperature shock and DNP in drosophila

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Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol

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Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation

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In vitro phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme a reductase: Analysis of 32P-labeled, inactivated enzyme

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The purification and properties of a protein kinase and the partial purification of a phosphoprotein phosphatase that inactivate and activate acetyl-CoA carboxylase

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Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.

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Substrate cycling between 5-amino-4-imidazolecarboxamide riboside and its monophosphate in isolated rat hepatocytes

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EXPERIMENTAL ACTIVATION OF SPECIFIC LOCI IN POLYTENE CHROMOSOMES OF DROSOPHILA

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Phosphorylation--dephosphorylation of rat liver 3-hydroxy 3-methylglutaryl coenzyme A reductase associated with changes in activity

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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

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Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase

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7 January 2021

Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes

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7 January 2021

Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.

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Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

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7 January 2021

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Immunological evidence that HMG-CoA reductase kinase-A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases

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7 January 2021

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

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7 January 2021

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR--an activator of AMP-activated protein kinase

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7 January 2021

Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP

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The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

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7 January 2021

Hormone-sensitive lipase--a multipurpose enzyme in lipid metabolism

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Catalytic subunits of the porcine and rat 5'-AMP-activated protein kinase are members of the SNF1 protein kinase family

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7 January 2021

Stimulation of rat liver AMP-activated protein kinase by AMP analogues

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7 January 2021

In vivo 31P nuclear magnetic resonance studies of arsenite induced changes in hepatic phosphate levels

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The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

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7 January 2021

Glucose repression in fungi

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7 January 2021

Role of the AMP-activated protein kinase in the cellular stress response

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7 January 2021

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

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7 January 2021

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

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Regulation of glycolysis and L-glycerol 3-phosphate concentration in rat epididymal adipose tissue in vitro. Role of phosphofructokinase

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase. A comparison of the modulation in vitro by phosphorylation and dephosphorylation to modulation of enzyme activity by feeding cholesterol- or cholestyramine-supplemented diets

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7 January 2021

Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat

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A cold-clamping technique for the rapid sampling of rat liver for studies on enzymes in separate cell fractions. Suitability for the study of enzymes regulated by reversible phosphorylation-dephosphorylation

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7 January 2021

Diurnal changes in the fraction of 3-hydroxy-3-methylglutaryl-CoA reductase in the active form in rat liver microsomal fractions

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7 January 2021

Acute effects of starvation and treatment of rats with anti-insulin serum, glucagon and catecholamines on the state of phosphorylation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase in vivo

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7 January 2021

The short-term regulation of hepatic acetyl-CoA carboxylase during starvation and re-feeding in the rat

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7 January 2021

Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes

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Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells

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Identification of a second human acetyl-CoA carboxylase gene

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3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation

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Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase

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Isolation of a wheat cDNA clone for an abscisic acid-inducible transcript with homology to protein kinases

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Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion

1 reference

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High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

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5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

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7 January 2021

Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase

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Isoform-specific purification and substrate specificity of the 5'-AMP-activated protein kinase

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AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1.

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A comprehensive set of sequence analysis programs for the VAX

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Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase

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Carbon Catabolite Repression Regulates Glyoxylate Cycle Gene Expression in Cucumber.

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Regulation of short-term changes in hepatic beta-hydroxy-beta-methylglutaryl-CoA reductase activity

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Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

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Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism

1 reference

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Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay

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Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities

1 reference

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Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

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Identification and role of the basal phosphorylation site on hormone-sensitive lipase

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Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion

1 reference

https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets

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https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Carbon catabolite repression in yeast

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7 January 2021

Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase

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7 January 2021

Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase

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https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia)

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https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.

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https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

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Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinas

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7 January 2021

The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA

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7 January 2021

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method

1 reference

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7 January 2021

A protein kinase substrate identified by the two-hybrid system

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https://api.crossref.org/works/10.1111%2FJ.1432-1033.1997.00259.X

7 January 2021

A yeast gene that is essential for release from glucose repression encodes a protein kinase

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7 January 2021

In vivo phosphorus-31 nuclear magnetic resonance reveals lowered ATP during heat shock of Tetrahymena

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Characterization of tobacco protein kinase NPK5, a homolog of Saccharomyces cerevisiae SNF1 that constitutively activates expression of the glucose-repressible SUC2 gene for a secreted invertase of S. cerevisiae

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7 January 2021

Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein

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Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase

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7 January 2021

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis

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Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes

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