Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer (Q24314577)

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English	Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer	scientific article

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scholarly article

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Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer (English)

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Hepatocyte nuclear factor 4 alpha

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GOA release 2020-03-11

Forkhead box A2

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GOA release 2020-03-11

regulation of blood coagulation

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GOA release 2020-03-11

author name string

H Ceelie

1

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C C Spaargaren-Van Riel

2

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M De Jong

3

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R M Bertina

4

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H L Vos

5

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language of work or name

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publication date

August 2003

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Journal of Thrombosis and Haemostasis

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1

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8

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1688-98

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Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression

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The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix

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Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

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TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4.

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vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1

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Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4.

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Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4.

1 reference

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Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome

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The molecular basis of blood coagulation

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The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

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Characterization of the Alu-rich 5'-flanking region of the human prothrombin-encoding gene: identification of a positive cis-acting element that regulates liver-specific expression

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Venous thrombosis: a multicausal disease

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The Sp-family of transcription factors

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Discovery and modeling of transcriptional regulatory regions

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The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism

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Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4

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SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization

1 reference

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The human prothrombin gene: transcriptional regulation in HepG2 cells

1 reference

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Nucleotide sequence of the gene for human prothrombin

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A new bacteriophage P1-derived vector for the propagation of large human DNA fragments

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Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

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Co-operation of the transcription factor hepatocyte nuclear factor-4 with Sp1 or Sp3 leads to transcriptional activation of the human haem oxygenase-1 gene promoter in a hepatoma cell line

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Inter-relation of coagulation factors and d-dimer levels in healthy individuals

1 reference

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Biochemistry and Physiology of Blood Coagulation

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The Prothrombin Gene and Its Liver-Specific Expression

1 reference

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Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden

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Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver

1 reference

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Functional characterization of the human factor VII 5'-flanking region

1 reference

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Liver-enriched transcription factor HNF-4 and ubiquitous factor NF-Y are critical for expression of blood coagulation factor X.

1 reference

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The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene

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Cloning and characterization of the human factor XI gene promoter: transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha ) is required for hepatocyte-specific expression of factor XI.

1 reference

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Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter

1 reference

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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1 reference

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Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription

1 reference

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DNA binding and transcription activation specificity of hepatocyte nuclear factor 4

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TRANSFAC: an integrated system for gene expression regulation

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Liver-enriched transcription factors and hepatocyte differentiation.

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Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters

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Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels

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