Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone (Q24313179)

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4 January 2020

title

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone (English)

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cytochrome P450 family 3 subfamily A member 4

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main subject

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cytochrome P450 family 2 subfamily A member 6

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cytochrome P450 family 2 subfamily E member 1

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cytochrome P450 family 1 subfamily A member 2

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cytochrome P450 family 2 subfamily C member 9

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cytochrome P450 family 2 subfamily D member 6

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cytochrome P450 family 2 subfamily B member 6

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cytochrome P450 family 2 subfamily C member 19

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steroid hydroxylase activity

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author

Miia Turpeinen

2

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4 January 2020

5

Olavi Pelkonen

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author name string

Tuomas Korhonen

1

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4 January 2020

Ari Tolonen

3

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Kari Laine

4

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language of work or name

English

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publication date

15 February 2008

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The Journal of Steroid Biochemistry and Molecular Biology

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published in

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volume

110

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page(s)

56-66

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issue

1-2

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Kinetics of norethindrone in women; I. Radioimmunoassay and concentrations during multiple dosing

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Kinetics of norethindrone in women. II. Single-dose kinetics

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Determination of estrogens and progestogens by mass spectrometric techniques (GC/MS, LC/MS and LC/MS/MS)

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Screening for anabolic steroids and related compounds in illegal cocktails by liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/quadrupole time-of-flight tandem mass spectrometry with accurate mass measurement

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Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.

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Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

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The effect of rifampicin on norethisterone pharmacokinetics

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Pharmacokinetics of norethindrone acetate in women

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Intraindividual comparison of pharmacokinetic parameters of d-norgestrel, lynestrenol and cyproterone acetate in 6 women

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7 January 2021

Serum levels and pharmacokinetics of norethisterone after ingestion of lynestrenol: its relation to dose and stage of the menstrual cycle

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Pharmacokinetics, pharmacodynamic and endometrial effects of a single dose of 200 mg norethisterone enanthate

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Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids

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The interaction between St John's wort and an oral contraceptive

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7 January 2021

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

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7 January 2021

Cytochrome P450 (CYP) inhibition screening: comparison of three tests.

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7 January 2021

Classification and pharmacology of progestins

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Cytochrome P-450-linked monooxygenase system and drug-induced spectral interactions in human liver microsomes

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7 January 2021

The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive

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Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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Substrate SARs in human P450s

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Gastrointestinal and systemic uptake of bismuth in mice after oral exposure

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Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

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Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers

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7 January 2021

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

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7 January 2021

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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7 January 2021

Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects

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Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

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Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

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Metabolism of [4-14C]lynestrenol in man

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Metabolism of lynestrenol to norethisterone by liver homogenate

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Pharmacokinetic interaction between bosentan and the oral contraceptives norethisterone and ethinyl estradiol.

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Identifiers

DOI

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4 January 2020

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