Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes (Q24313056)

cell surface receptor signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

L Sun

1

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H D Youn

2

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C Loh

3

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M Stolow

4

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W He

5

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J O Liu

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

6

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language of work or name

English

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publication date

June 1998

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published in

Immunity

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volume

8

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page(s)

703-11

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issue

6

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cites work

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

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Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

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The structure and regulation of protein phosphatases

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Signal transmission between the plasma membrane and nucleus of T lymphocytes

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations

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Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

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A novel genetic system to detect protein-protein interactions

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

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7 January 2021

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

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7 January 2021

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

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Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

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7 January 2021

Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells

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7 January 2021

Calcium and T lymphocyte activation

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7 January 2021

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

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7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells

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7 January 2021

Functional domain structure of calcineurin A: mapping by limited proteolysis

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7 January 2021

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

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7 January 2021

Distinct tissue and cellular distribution of two major isoforms of calcineurin

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7 January 2021

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

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7 January 2021

Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

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7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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7 January 2021

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

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7 January 2021

T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1.

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Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.

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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

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7 January 2021

PEST sequences and regulation by proteolysis

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7 January 2021

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

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7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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7 January 2021

Protein serine/threonine phosphatases--new avenues for cell regulation

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7 January 2021

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.

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7 January 2021

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

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7 January 2021

JNK is involved in signal integration during costimulation of T lymphocytes.

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7 January 2021

The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase

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7 January 2021

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

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7 January 2021

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

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7 January 2021

Inhibition of the CD3-mediated calcium signal by protein kinase C activators in human T (Jurkat) lymphoblastoid cells

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7 January 2021

Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)

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7 January 2021