Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity (Q24312827)

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Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity

Language	Label	Description	Also known as
English	Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity	scientific article	Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity

Statements

scholarly article

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Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity (English)

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crystal structure

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4

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Alexander Kotzsch

1

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2

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author name string

Axel Seher

3

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Thomas D Müller

5

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language of work or name

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publication date

8 April 2009

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The EMBO Journal

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28

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937-47

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7

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Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

BMP receptor signaling is required for postnatal maintenance of articular cartilage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Molecular recognition of BMP-2 and BMP receptor IA

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Crystal structure of the BMP-2-BRIA ectodomain complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

19 March 2017

Structure of the ternary signaling complex of a TGF-beta superfamily member

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

A single residue of GDF-5 defines binding specificity to BMP receptor IB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

Crystal structure of recombinant human growth and differentiation factor 5: evidence for interaction of the type I and type II receptor-binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

TGFbeta signaling: receptors, transducers, and Mad proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

27 September 2017

A piston model for transmembrane signaling of the aspartate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

30 May 2018

GDF5 coordinates bone and joint formation during digit development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

30 May 2018

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670865

30 May 2018

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.37

21 January 2018

Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.37

21 January 2018

The mutational spectrum of brachydactyly type C

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.37

21 January 2018

Du Pan syndrome phenotype caused by heterozygous pathogenic mutations in CDMP1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19229295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel mutation in GDF5 causes autosomal dominant symphalangism in two Chinese families

1 reference

https://pubmed.ncbi.nlm.nih.gov/19229295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An experimental investigation into the early development of the chick elbow joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/19229295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of the diarthrodial joints in the rat embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19229295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/EMBOJ.2009.37

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