Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI (Q24311413)

Ubiquitin conjugating enzyme E2 T

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FA complementation group L

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ubiquitin protein ligase binding

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

3

M Madan Babu

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author name string

Arno F Alpi

series ordinal

1

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Paul E Pace

series ordinal

2

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Ketan J Patel

series ordinal

4

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language of work or name

English

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publication date

26 December 2008

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published in

Molecular Cell

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volume

32

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page(s)

767-77

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issue

6

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cites work

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RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

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The Fanconi family adds a fraternal twin

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Drosophila homologs of FANCD2 and FANCL function in DNA repair

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C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair

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Fanconi anemia and DNA replication repair

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The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

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A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

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Deubiquitination of FANCD2 is required for DNA crosslink repair

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Tandem affinity purification and identification of protein complex components.

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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BRCA1-independent ubiquitination of FANCD2

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The emerging genetic and molecular basis of Fanconi anaemia

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A novel ubiquitin ligase is deficient in Fanconi anemia

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

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The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

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The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly

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FANCE: the link between Fanconi anaemia complex assembly and activity

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

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Systematic identification of novel protein domain families associated with nuclear functions

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Solution structure of the RWD domain of the mouse GCN2 protein

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UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination

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FANCG is phosphorylated at serines 383 and 387 during mitosis

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Mechanisms underlying ubiquitination

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The Fanconi anemia core complex associates with chromatin during S phase

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Evidence for subcomplexes in the Fanconi anemia pathway

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