Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor (Q24311075)

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23 October 2019

title

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor (English)

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23 October 2019

4

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23 October 2019

7

J Schlessinger

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23 October 2019

author name string

R Nishimura

1

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23 October 2019

W Li

2

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23 October 2019

A Kashishian

3

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23 October 2019

M Zhou

5

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23 October 2019

J Cooper

6

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23 October 2019

publication date

1 November 1993

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Molecular and Cellular Biology

23 October 2019

language of work or name

English

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published in

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23 October 2019

volume

13

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23 October 2019

issue

11

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23 October 2019

page(s)

6889-6896

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SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

23 October 2019

cites work

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A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

19 March 2017

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19 March 2017

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Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

19 March 2017

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The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

19 March 2017

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Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma

19 March 2017

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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

19 March 2017

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GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

19 March 2017

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The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

19 March 2017

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Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

19 March 2017

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

19 March 2017

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Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo

19 March 2017

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

19 March 2017

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

19 March 2017

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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

19 March 2017

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SH2 domains recognize specific phosphopeptide sequences

19 March 2017

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Signal transduction by receptors with tyrosine kinase activity

19 March 2017

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SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

19 March 2017

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

19 March 2017

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

19 March 2017

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Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

19 March 2017

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

19 March 2017

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19 March 2017

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19 March 2017

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7 April 2017

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7 April 2017

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

7 April 2017

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7 April 2017

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7 April 2017

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Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively

27 September 2017

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Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase

27 September 2017

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27 September 2017

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Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways

27 September 2017

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Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

27 September 2017

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SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma

27 September 2017

1 reference

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Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

27 September 2017

1 reference

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

27 September 2017

1 reference

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The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

27 September 2017

1 reference

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Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction

27 September 2017

1 reference

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Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells

30 May 2018

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Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach.

30 May 2018

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Transduction of circular membrane ruffling by the platelet-derived growth factor beta-receptor is dependent on its kinase insert

30 May 2018

1 reference

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Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

30 May 2018

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A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF.

30 May 2018

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29 November 2018

Identifiers

DOI

10.1128/MCB.13.11.6889

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7692233%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

1 reference

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23 October 2019

PubMed publication ID

7692233

1 reference