Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription (Q24310643)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

title

Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

Cyclin dependent kinase 9

2 January 2020

main subject

cell biology

0 references

1 reference

GOA release 2020-03-11

author

Arianna Sabò

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Marina Lusic

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Mauro Giacca

4

1 reference

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2 January 2020

author name string

Anna Cereseto

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

language of work or name

English

0 references

publication date

4 February 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

2 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

volume

28

1 reference

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2 January 2020

page(s)

2201-2212

1 reference

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2 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

Regulation of P-TEFb elongation complex activity by CDK9 acetylation

2 January 2020

cites work

1 reference

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

19 March 2017

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

19 March 2017

1 reference

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Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter

19 March 2017

1 reference

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Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

19 March 2017

1 reference

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MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

19 March 2017

1 reference

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Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein

19 March 2017

1 reference

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Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding

19 March 2017

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Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome

19 March 2017

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

19 March 2017

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

19 March 2017

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Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter

19 March 2017

1 reference

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HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter

19 March 2017

1 reference

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Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages

19 March 2017

1 reference

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Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5

19 March 2017

1 reference

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Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription

19 March 2017

1 reference

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Controlling the elongation phase of transcription with P-TEFb

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Upregulation of cyclin T1/CDK9 complexes during T cell activation

19 March 2017

1 reference

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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

19 March 2017

1 reference

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TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines

19 March 2017

1 reference

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P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

19 March 2017

1 reference

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Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

7 April 2017

1 reference

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Crystal structure of cyclin-dependent kinase 2

7 April 2017

1 reference

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Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

7 April 2017

1 reference

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Human origins of DNA replication selected from a library of nascent DNA.

27 September 2017

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A structural perspective of CTD function

27 September 2017

1 reference

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The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

27 September 2017

1 reference

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Nuclear organization and the control of HIV-1 transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Regulation of the p300 HAT domain via a novel activation loop.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

HIV-1 tat transcriptional activity is regulated by acetylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

Coordination of a transcriptional switch by HMGI(Y) acetylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268415

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18250157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01557-07

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250157%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

2 references