Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells (Q24307750)

fungiform papilla formation

1 reference

Histone deacetylase 2

1 reference

Histone deacetylase 1

1 reference

author name string

Matthew LeBoeuf

1

0 references

Anne Terrell

2

0 references

Sohum Trivedi

3

0 references

Satrajit Sinha

4

0 references

Jonathan A Epstein

5

0 references

Eric N Olson

6

0 references

Edward E Morrisey

7

0 references

Sarah E Millar

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

8

0 references

language of work or name

English

0 references

publication date

14 December 2010

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published in

Developmental Cell

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volume

19

0 references

issue

6

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page(s)

807-18

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cites work

1 reference

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Acetylation is indispensable for p53 activation

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p63 regulates proliferation and differentiation of developmentally mature keratinocytes

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

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An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate

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WAF1, a potential mediator of p53 tumor suppression

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p63 Is essential for the proliferative potential of stem cells in stratified epithelia

19 March 2017

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Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation

19 March 2017

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

19 March 2017

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

19 March 2017

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

19 March 2017

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Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction

19 March 2017

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Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

19 March 2017

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Wnt-beta-catenin signaling initiates taste papilla development

19 March 2017

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p63 is upstream of IKK alpha in epidermal development

19 March 2017

1 reference

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p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

19 March 2017

1 reference

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

19 March 2017

1 reference

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p63 is a p53 homologue required for limb and epidermal morphogenesis

19 March 2017

1 reference

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Multivalent engagement of chromatin modifications by linked binding modules

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

7 April 2017

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Asymmetric cell divisions promote stratification and differentiation of mammalian skin

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p63 in skin development and ectodermal dysplasias

7 April 2017

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DNMT1 maintains progenitor function in self-renewing somatic tissue

27 September 2017

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p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes

27 September 2017

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Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

27 September 2017

1 reference

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Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

27 September 2017

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The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines.

27 September 2017

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Growth arrest and DNA damage-45 alpha (GADD45alpha).

27 September 2017

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Claudin-1 is a p63 target gene with a crucial role in epithelial development

27 September 2017

1 reference

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IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias

27 September 2017

1 reference

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

27 September 2017

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Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis

27 September 2017

1 reference

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Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation

27 September 2017

1 reference

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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

p63 induces key target genes required for epidermal morphogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Control of keratinocyte proliferation and differentiation by p63.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

The mammary bud as a skin appendage: unique and shared aspects of development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Srcasm modulates EGF and Src-kinase signaling in keratinocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Links between signal transduction, transcription and adhesion in epithelial bud development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Spatial repression of PCNA by p53 during kidney development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Programming gene expression in developing epidermis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003338

Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients

29 November 2018

1 reference

12 December 2020

p63: revving up epithelial stem-cell potential

1 reference

12 December 2020

Expression of GATA-3 in epidermis and hair follicle: relationship to p63

1 reference

12 December 2020

The role of p63 in epidermal morphogenesis and neoplasia

1 reference

12 December 2020

Histone deacetylase inhibitors as potential anti-skin cancer agents

1 reference

12 December 2020

10.1016/J.DEVCEL.2010.10.015

Identifiers

DOI

1 reference

4913977

4913977

1 reference

1 reference

1 reference