Akt is negatively regulated by the MULAN E3 ligase (Q24307478)

negative regulation of protein kinase B signaling

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Seunghee Bae

1

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Sun-Yong Kim

2

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Jin Hyuk Jung

3

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Yeongmin Yoon

4

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Hwa Jun Cha

5

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Hyunjin Lee

6

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Karam Kim

7

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Jongran Kim

8

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In-Sook An

9

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Jongdoo Kim

10

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Hong-Duck Um

11

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In-Chul Park

12

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Su-Jae Lee

13

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Seon Young Nam

14

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Young-Woo Jin

15

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Jae Ho Lee

16

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Sungkwan An

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt

17

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language of work or name

English

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publication date

May 2012

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published in

Cell Research

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volume

22

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page(s)

873-85

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issue

5

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cites work

1 reference

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Negative Regulation of AKT Activation by BRCA1

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GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

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Akt and CHIP coregulate tau degradation through coordinated interactions

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

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19 March 2017

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Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration

19 March 2017

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Akt regulates growth by directly phosphorylating Tsc2

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 April 2017

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Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium

7 April 2017

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27 September 2017

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Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity

27 September 2017

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27 September 2017

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27 September 2017

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Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity

27 September 2017

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27 September 2017

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Ten years of protein kinase B signalling: a hard Akt to follow

27 September 2017

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

27 September 2017

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Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

27 September 2017

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Regulation of protein kinase B.

27 September 2017

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

27 September 2017

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

27 September 2017

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Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.

30 May 2018

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The Akt isoforms are present at distinct subcellular locations

30 May 2018

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Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine.

21 January 2018

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Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry

21 January 2018

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Signal transduction: signaling specificity- a complex affair

21 January 2018

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Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells

21 January 2018

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Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells

21 January 2018

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Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol

21 January 2018

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Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.

29 November 2018

1 reference

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