The protease inhibitor bikunin, a novel anti-metastatic agent (Q24305858)

Alpha-1-microglobulin/bikunin precursor

Europe PubMed Central

title

The protease inhibitor bikunin, a novel anti-metastatic agent (English)

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main subject

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negative regulation of JNK cascade

GOA release 2020-03-11

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Characterization of placental bikunin, a novel human serine protease inhibitor

GOA release 2020-03-11

author name string

Mika Suzuki

series ordinal

2

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Yasuyuki Hirashima

series ordinal

3

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Toshihiko Terao

series ordinal

4

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language of work or name

English

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publication date

May 2003

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published in

Biological Chemistry

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volume

384

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page(s)

749-54

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issue

5

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cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.083

Cancer treatment with inhibitors of urokinase-type plasminogen activator and plasmin

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Adhesion proteins in the biology of breast cancer: contribution of CD44.

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Urinary trypsin inhibitor prevents uterine muscle contraction by inhibition of Ca++ influx

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Matrix metalloproteinases and metastasis

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Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells

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Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent

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A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis

21 January 2018

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Identification of structural domains in inter-alpha-trypsin involved in calcium oxalate crystallization.

21 January 2018

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Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.083

A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade

21 January 2018

1 reference

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Down-regulation of interleukin-8 gene expression in HL60 cell line by human Kunitz-type trypsin inhibitor

21 January 2018

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Invasion by esophageal cancer cells: functional contribution of the urokinase plasminogen activation system, and inhibition by antisense oligonucleotides to urokinase or urokinase receptor

21 January 2018

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Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours

21 January 2018

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Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

21 January 2018

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Inhibition of NF-kappa B-Rel A expression by antisense oligodeoxynucleotides suppresses synthesis of urokinase-type plasminogen activator (uPA) but not its inhibitor PAI-1.

21 January 2018

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Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins

21 January 2018

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Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells

21 January 2018

1 reference

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Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin

21 January 2018

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Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model

21 January 2018

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Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma

21 January 2018

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cDNA transfection of amino-terminal fragment of urokinase efficiently inhibits cancer cell invasion and metastasis

21 January 2018

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Inhibition of metastasis of Lewis lung carcinoma by urinary trypsin inhibitor in experimental and spontaneous metastasis models

21 January 2018

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7 January 2021

Kunitz-type trypsin inhibitor prevents LPS-induced increase of cytosolic free Ca2+ in human neutrophils and HUVEC cells

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7 January 2021

The role of chondroitin sulfate chains of urinary trypsin inhibitor in inhibition of LPS-induced increase of cytosolic free Ca2+ in HL60 cells and HUVEC cells

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https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

Suppression of urokinase-type plasminogen activator expression from human ovarian cancer cells by urinary trypsin inhibitor

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

Urinary trypsin inhibitor suppresses vascular smooth muscle contraction by inhibition of Ca2+ influx

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro

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https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.

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https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021

A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo

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7 January 2021

Effects of urinary trypsin inhibitor on myometrial contraction in term and preterm deliveries

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https://api.crossref.org/works/10.1515%2FBC.2003.083

7 January 2021