C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins (Q24305258)

transmembrane receptor protein tyrosine kinase signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

guanine

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author name string

S Tanaka

1

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T Morishita

2

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Y Hashimoto

3

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S Hattori

4

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S Nakamura

5

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M Shibuya

6

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K Matuoka

7

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T Takenawa

8

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T Kurata

9

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K Nagashima

Proceedings of the National Academy of Sciences of the United States of America

10

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language of work or name

English

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publication date

12 April 1994

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published in

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volume

91

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page(s)

3443-7

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issue

8

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cites work

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Two species of human CRK cDNA encode proteins with distinct biological activities

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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SH2 domains recognize specific phosphopeptide sequences

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Signal transduction by receptors with tyrosine kinase activity

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IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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Identification of a ten-amino acid proline-rich SH3 binding site

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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Signalling through SH2 and SH3 domains

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

27 September 2017

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Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins

27 September 2017

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Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

27 September 2017

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Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells

27 September 2017

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Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae

27 September 2017

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The Son of sevenless Gene Product: a Putative Activator of Ras

27 September 2017

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A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity

27 September 2017

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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

27 September 2017

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The product of the cellular crk gene consists primarily of SH2 and SH3 regions

27 September 2017

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The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

27 September 2017

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The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

27 September 2017

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30 May 2018

Exchange rate mechanisms

1 reference

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29 November 2018

Identifiers

DOI

10.1073/PNAS.91.8.3443

1 reference

3394248

ADS bibcode

1994PNAS...91.3443T

0 references

3394248

1 reference

1 reference

1 reference