The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering (Q24304357)

9

object named as

Yves Engelborghs

0 references

author name string

Jelle Hendrix

1

0 references

Rik Gijsbers

2

0 references

Jan De Rijck

3

0 references

Arnout Voet

4

0 references

Jun-ichi Hotta

5

0 references

Melissa McNeely

6

0 references

Johan Hofkens

Creative Commons Attribution-NonCommercial 2.5 Generic

7

0 references

language of work or name

English

0 references

publication date

March 2011

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published in

Nucleic Acids Research

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volume

39

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issue

4

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page(s)

1310-25

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copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3045605/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

19 March 2017

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

19 March 2017

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

19 March 2017

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

19 March 2017

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Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress

19 March 2017

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Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing

19 March 2017

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19 March 2017

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High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

7 April 2017

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LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin

27 September 2017

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27 September 2017

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

27 September 2017

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Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

27 September 2017

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Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

27 September 2017

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

27 September 2017

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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

27 September 2017

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Evidence for a common mode of transcription factor interaction with chromatin as revealed by improved quantitative fluorescence recovery after photobleaching.

27 September 2017

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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

27 September 2017

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LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

27 September 2017

1 reference

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27 September 2017

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Continuous photobleaching in vesicles and living cells: a measure of diffusion and compartmentation

27 September 2017

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27 September 2017

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27 September 2017

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

27 September 2017

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27 September 2017

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27 September 2017

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Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis

27 September 2017

1 reference

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Anomalous subdiffusion is a measure for cytoplasmic crowding in living cells

27 September 2017

1 reference

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Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins

27 September 2017

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Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

LEDGF, a survival factor, activates stress-related genes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Light-induced flickering of DsRed provides evidence for distinct and interconvertible fluorescent states

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Fluorescence recovery after photobleaching: a versatile tool for mobility and interaction measurements in pharmaceutical research

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Dynamics of fluorescence fluctuations in green fluorescent protein observed by fluorescence correlation spectroscopy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells

27 September 2017

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Dark states in monomeric red fluorescent proteins studied by fluorescence correlation and single molecule spectroscopy

27 September 2017

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Precise measurement of diffusion coefficients using scanning fluorescence correlation spectroscopy

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

HotPatch: a statistical approach to finding biologically relevant features on protein surfaces

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Interphase chromosomes undergo constrained diffusional motion in living cells

30 May 2018

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30 May 2018

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The role of chromatin conformations in diffusional transport of chromatin-binding proteins: Cartesian lattice simulations

30 May 2018

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Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75.

29 November 2018

1 reference

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LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045605

Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us?

29 November 2018

1 reference

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DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF

29 November 2018

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12 December 2020

Fluorescence correlation spectroscopy with single-molecule sensitivity on cell and model membranes

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12 December 2020

Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells

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12 December 2020

LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes

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12 December 2020

Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer

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Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKQ933

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1093/NAR/GKQ933

1 reference

2600260

2600260

1 reference

1 reference

1 reference