Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway (Q24304210)

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D H Shin

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K S Jang

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H J Kim

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Gu Kong

An essential role for p300/CBP in the cellular response to hypoxia

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language of work or name

English

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publication date

10 November 2011

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published in

Oncogene

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volume

30

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page(s)

4578-89

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issue

45

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cites work

1 reference

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HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

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PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

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Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

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Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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Ubiquitination regulates PTEN nuclear import and tumor suppression

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X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

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HIF-1 regulation: not so easy come, easy go

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta

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Phosphorylation of HDM2 by Akt.

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Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression

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PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).

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Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

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Low expression of Mel-18 predicts poor prognosis in patients with breast cancer.

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High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.

31 March 2020

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STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

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Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

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Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha

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DJ-1, a novel regulator of the tumor suppressor PTEN.

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Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer

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Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha

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Overexpression of PTEN induces cell growth arrest and apoptosis in human breast cancer ZR-75-1 cells

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PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells

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Activation of the HIF pathway in cancer

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Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

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Bridging the gap between cytotoxic and biologic therapy with metronomic topotecan and pazopanib in ovarian cancer.

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The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

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Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.174

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.174

Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

31 March 2020

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SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.174

PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells

31 March 2020

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Stem cells and cancer; the polycomb connection

31 March 2020

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ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

31 March 2020

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Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.174

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1173086

1026432104

0 references

1173086

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference