Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion (Q24303907)

Profilin 1

1 reference

Enah/Vasp-like

1 reference

Profilin 2

1 reference

negative regulation of ruffle assembly

1 reference

Ena-vasodilator stimulated phosphoprotein

1 reference

Profilin 2

1 reference

1 reference

11

R Dyche Mullins

0 references

Joan Brugge

12

object named as

Joan S Brugge

0 references

author name string

Ghassan Mouneimne

1

0 references

Scott D Hansen

2

0 references

Laura M Selfors

3

0 references

Lara Petrak

4

0 references

Michele M Hickey

5

0 references

Lisa L Gallegos

6

0 references

Kaylene J Simpson

7

0 references

James Lim

8

0 references

Frank B Gertler

9

0 references

John H Hartwig

Ena/VASP: towards resolving a pointed controversy at the barbed end

10

0 references

language of work or name

English

0 references

publication date

13 November 2012

0 references

published in

Cancer Cell

0 references

volume

22

0 references

issue

5

0 references

page(s)

615-30

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

X-ray structure determination of human profilin II: A comparative structural analysis of human profilins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Cellular motility driven by assembly and disassembly of actin filaments

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

A gene-expression signature as a predictor of survival in breast cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Rac activation and inactivation control plasticity of tumor cell movement

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Cloning and expression of a novel human profilin variant, profilin II

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Genes that mediate breast cancer metastasis to lung

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Plasticity of cell migration: a multiscale tuning model

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Genomic and epigenomic integration identifies a prognostic signature in colon cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

The filamins: organizers of cell structure and function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Actin dynamics at the leading edge: from simple machinery to complex networks.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

The interaction of proline-rich ligands with profilin probed with an enzyme-linked immunosorbent assay

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Local cortical tension by myosin II guides 3D endothelial cell branching

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

27 September 2017

The profile of profilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Modelling glandular epithelial cancers in three-dimensional cultures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

The role of profilin complexes in cell motility and other cellular processes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stages.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

29 November 2018

Cofilin takes the lead.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500527

Predicting features of breast cancer with gene expression patterns

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23153535

12 December 2020

inferred from PubMed ID database lookup

The humoral immune system has a key prognostic impact in node-negative breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23153535

12 December 2020

inferred from PubMed ID database lookup

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.09.027

7 January 2021

Molecular mechanism of Ena/VASP-mediated actin-filament elongation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.09.027

7 January 2021

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.09.027

7 January 2021

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2012.09.027

7 January 2021

10.1016/J.CCR.2012.09.027

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

23153535

1 reference